{"id":"W2114905010","doi":"10.1158/1535-7163.1127.3.9","title":"Brain tumor cell lines resistant to <i>O</i>6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have <i>O</i>6-alkylguanine-DNA alkyltransferase mutations","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Carmustine; Nitrosourea; Cell culture; Cancer research; Biology; Molecular biology; Chemotherapy; Etoposide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389675,0.0004271496,0.0003325846,0.0002785877,0.0001610864,0.0002320908,0.0002956681,0.0002065288,0.0009034519],"category_scores_gemma":[0.0001245317,0.0001589208,0.0002832219,0.0002620284,0.0002146394,0.0000973563,0.0001681731,0.0004803778,0.000569954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003242645,"about_ca_system_score_gemma":0.0002858543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003417279,"about_ca_topic_score_gemma":0.006183298,"domain_scores_codex":[0.999811,0.00002171654,0.00002996576,0.00003788634,0.00006412082,0.00003534178],"domain_scores_gemma":[0.9998956,0.00001843415,0.00002554553,0.0000268632,0.00001313382,0.00002047031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007457175,0.0000534589,0.0008848915,0.0000255809,0.000008817317,0.000100476,0.00003094846,0.0001050437,0.9974352,0.0001519754,0.00007373579,0.001055378],"study_design_scores_gemma":[0.00004075504,0.0006587561,0.01134103,0.000004717504,0.00003161083,0.0008978611,0.00005612927,0.001033565,0.9803423,0.00005527055,0.005529884,0.000008065647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933749,0.0004962139,0.002540682,0.00005095609,0.00001262982,0.0001125685,0.001508386,0.00007804072,0.001825511],"genre_scores_gemma":[0.9805554,0.0006922639,0.01056669,0.0000453904,0.000006329898,0.0001227268,0.004726664,0.00003760054,0.00324704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003417279,"threshold_uncertainty_score":0.00679481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190603776951182,"score_gpt":0.2658752838930298,"score_spread":0.253969246123518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}