{"id":"W2114905010","doi":"10.1158/1535-7163.1127.3.9","title":"Brain tumor cell lines resistant to <i>O</i>6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have <i>O</i>6-alkylguanine-DNA alkyltransferase mutations","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Carmustine; Nitrosourea; Cell culture; Cancer research; Biology; Molecular biology; Chemotherapy; Etoposide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002762281,0.0007386954,0.0004922068,0.0001725985,0.0002473283,0.0001313798,0.0007169978,0.0003148611,0.00006799478],"category_scores_gemma":[0.00003774698,0.0007715501,0.000411528,0.0004428688,0.0001518648,0.00001663847,0.000124054,0.0003211727,0.00003529207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623595,"about_ca_system_score_gemma":0.000578372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002126446,"about_ca_topic_score_gemma":0.000455596,"domain_scores_codex":[0.9965803,0.0001352697,0.0006338885,0.00112479,0.0005937213,0.0009320297],"domain_scores_gemma":[0.9978538,0.00002734199,0.0001801919,0.001181726,0.0003495527,0.0004073599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005323965,0.0002994428,0.00006174889,0.00004949217,0.0002510344,0.00009537657,0.0004670642,0.002852719,0.9932578,0.0003691295,0.0005436002,0.001220182],"study_design_scores_gemma":[0.003069636,0.0008815216,0.00006957812,0.00005543289,0.0001361793,0.00003034592,0.0002237694,0.00004629446,0.8969257,0.0006398516,0.09707688,0.0008448319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9414667,0.003718141,0.04349187,0.008165933,0.0004269355,0.001264342,0.0003547674,0.0001835587,0.0009277511],"genre_scores_gemma":[0.9492165,0.000381348,0.007830583,0.04012221,0.000397877,0.000365414,0.0002701756,0.000304166,0.001111769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09653328,"threshold_uncertainty_score":0.9994736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190603776951182,"score_gpt":0.2658752838930298,"score_spread":0.253969246123518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}