{"id":"W2114918316","doi":"10.4049/jimmunol.169.9.4951","title":"Efficient Priming of CD4+ and CD8+ T Cells by DNA Vaccination Depends on Appropriate Targeting of Sufficient Levels of Immunologically Relevant Antigen to Appropriate Processing Pathways","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Priming (agriculture); Biology; DNA vaccination; T cell; CD8; Cell biology; Cytotoxic T cell; Acquired immune system; Immune system; Antigen; Adoptive cell transfer; Immunology; Immunization; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636084,0.0006241029,0.0004211188,0.000319074,0.0001372995,0.0004889684,0.0002392813,0.0007354757,0.001409837],"category_scores_gemma":[0.0003837801,0.000287803,0.0002537821,0.0001622383,0.0004398259,0.0004804836,0.0003244835,0.0009836335,0.0007889873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003385042,"about_ca_system_score_gemma":0.0003939153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428446,"about_ca_topic_score_gemma":0.0002915257,"domain_scores_codex":[0.9997103,0.00005835012,0.00002993053,0.00006914699,0.00006778137,0.0000645305],"domain_scores_gemma":[0.9998024,0.00006762535,0.000056158,0.00002116802,0.00001966858,0.00003303399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003806611,0.00003048258,0.00009522616,0.00004348502,0.000002533527,0.00001578286,0.000009847318,0.0001166241,0.9982016,0.0001054087,0.00001293262,0.001327935],"study_design_scores_gemma":[0.0000387947,0.0005837411,0.001214582,0.00001458822,0.00001342834,0.0001235109,0.00002038856,0.001273484,0.9948831,0.0001853252,0.001644171,0.000005022545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625042,0.002495386,0.0309864,0.0002894177,0.00008965673,0.0003542974,0.0002810274,0.0003288169,0.002670959],"genre_scores_gemma":[0.9648857,0.001421938,0.03063141,0.0001599212,0.00005103564,0.000274187,0.0003717241,0.00005595577,0.00214809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409837,"threshold_uncertainty_score":0.004716337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806649926418858,"score_gpt":0.2265957183007917,"score_spread":0.2085292190366031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}