{"id":"W2114922173","doi":"10.1113/jphysiol.2006.109702","title":"Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D","year":2006,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mitochondrial permeability transition pore; Denervation; Mitochondrion; Cyclophilin; Skeletal muscle; Cell biology; Calcium; Internal medicine; Muscle atrophy; Chemistry; In vivo; Programmed cell death; Endocrinology; Biology; Biochemistry; Medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003955875,0.0000578792,0.0001233058,0.00001315711,0.00007469624,0.000001793095,0.0001450053,0.00006697182,0.00001353055],"category_scores_gemma":[0.000105174,0.00002590566,0.00006956254,0.00004456502,0.0002195419,0.000004767208,0.00004541333,0.00008590458,8.182922e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002790445,"about_ca_system_score_gemma":0.00003156038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006423877,"about_ca_topic_score_gemma":0.00002533484,"domain_scores_codex":[0.9991004,0.0004528089,0.0002545828,0.00006588078,0.00006542537,0.00006085132],"domain_scores_gemma":[0.999314,0.00006924955,0.0003173471,0.0001694663,0.0001194931,0.00001048187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002362494,0.00004401109,0.0004524715,0.00001257921,0.000007228415,9.781765e-8,0.0001560878,0.0004015526,0.9983379,0.00003418096,0.0001452437,0.0001724527],"study_design_scores_gemma":[0.0003271503,0.0002922327,0.1089956,0.00002223373,0.00003449741,0.00004942526,0.0001868782,0.00003263919,0.8881503,0.00162628,0.0002503197,0.00003243011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986433,0.0003224989,0.0004006966,0.0003979801,0.0000954278,0.00009970868,0.000005911543,7.553908e-7,0.0000336733],"genre_scores_gemma":[0.9994953,0.00006350969,0.0001083934,0.00008496026,0.0002181464,0.000001308219,0.000008541071,0.000003729862,0.00001609198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1101876,"threshold_uncertainty_score":0.1056402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008915653814620637,"score_gpt":0.2239047338151899,"score_spread":0.2149890800005693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}