{"id":"W2114942701","doi":"10.1172/jci17892","title":"Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":458,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; University of Cincinnati; Heart and Stroke Foundation of Canada","keywords":"Phospholamban; Dilated cardiomyopathy; Heart failure; Internal medicine; Cardiomyopathy; Biology; Endocrinology; Null allele; Transplantation; Gene targeting; Cardiac function curve; Endoplasmic reticulum; Phenotype; Cell biology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002544461,0.0005890247,0.000325577,0.0004992897,0.0001609393,0.0002559276,0.0002010945,0.0005882039,0.003889825],"category_scores_gemma":[0.0002056432,0.0001865818,0.0002004971,0.0001742691,0.0003834469,0.0001914744,0.0002837221,0.0004087035,0.001159786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164523,"about_ca_system_score_gemma":0.0001348332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001409712,"about_ca_topic_score_gemma":0.0002044192,"domain_scores_codex":[0.9997968,0.00003131148,0.0000309605,0.0000706307,0.00004951401,0.0000207765],"domain_scores_gemma":[0.9998595,0.00002855368,0.00004320533,0.00001985425,0.00000819244,0.00004074725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004580384,0.00009092721,0.001119864,0.00005594346,0.00001842549,0.002491499,0.00003821498,0.00007857734,0.9916601,0.0004839087,0.00021178,0.003292701],"study_design_scores_gemma":[0.0003204568,0.001474804,0.03271283,0.00006630167,0.0001415307,0.05643636,0.00009108624,0.001738131,0.8843002,0.0008774021,0.02180258,0.0000382241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871262,0.00149448,0.006092113,0.0002623722,0.00009152716,0.00006036805,0.00138155,0.0003189084,0.003172562],"genre_scores_gemma":[0.9908482,0.001070593,0.003350533,0.0001209478,0.00002671989,0.00006593601,0.001504809,0.00009703534,0.002915267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003889825,"threshold_uncertainty_score":0.01301277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07356511232142594,"score_gpt":0.3914751218950633,"score_spread":0.3179100095736374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}