{"id":"W2114942701","doi":"10.1172/jci17892","title":"Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":458,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; University of Cincinnati; Heart and Stroke Foundation of Canada","keywords":"Phospholamban; Dilated cardiomyopathy; Heart failure; Internal medicine; Cardiomyopathy; Biology; Endocrinology; Null allele; Transplantation; Gene targeting; Cardiac function curve; Endoplasmic reticulum; Phenotype; Cell biology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002766949,0.0001465348,0.0008679999,0.0001344658,0.0001063054,0.00002148732,0.00005765132,0.000294624,0.000005456063],"category_scores_gemma":[0.006275542,0.0001225298,0.0002276442,0.0001820042,0.0004254098,0.0001220101,0.00002001859,0.001275422,0.000002271688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004339666,"about_ca_system_score_gemma":0.0001481964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002282896,"about_ca_topic_score_gemma":0.000004056874,"domain_scores_codex":[0.9968699,0.0007016587,0.00169237,0.0002472731,0.0002615847,0.0002272293],"domain_scores_gemma":[0.9980496,0.0007428218,0.0004602422,0.0001821256,0.0002260925,0.0003390952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000779977,0.0002802585,0.8289331,0.0001416881,0.0002394564,0.001264397,0.0005841786,0.00004052991,0.1596668,0.00549056,0.000695668,0.001883463],"study_design_scores_gemma":[0.003814593,0.001607577,0.9737357,0.0004070971,0.0002089344,0.0003165234,0.00003861122,0.00001929841,0.01121815,0.008363949,0.0001171978,0.0001523774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980494,0.0001641315,0.00003339898,0.001161176,0.0001451744,0.0001240332,0.000004559717,0.00001268061,0.0003053901],"genre_scores_gemma":[0.9981992,0.00003160818,0.0006756627,0.0003057956,0.0006461644,0.000001749452,0.00001166495,0.0000145751,0.0001135571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1484486,"threshold_uncertainty_score":0.7512863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07356511232142594,"score_gpt":0.3914751218950633,"score_spread":0.3179100095736374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}