{"id":"W2114960004","doi":"10.1093/oxfordjournals.jbchem.a003237","title":"Epitope Distribution of Randomly Established Monoclonal Antibodies against Human Type II DNA Topoisomerases","year":2002,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Epitope; Monoclonal antibody; Topoisomerase; Molecular biology; Antibody; Epitope mapping; DNA; Antigen; Biology; Linear epitope; Chemistry; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980207,0.0001378951,0.0002166099,0.00001956747,0.0001410797,0.00001457072,0.0002959055,0.0001055153,0.0000650697],"category_scores_gemma":[0.00006460364,0.00009949453,0.0001467194,0.00009040548,0.0001250333,0.000006184192,0.00008562679,0.0001315258,8.334421e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002086028,"about_ca_system_score_gemma":0.00004567043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004680142,"about_ca_topic_score_gemma":0.000001455966,"domain_scores_codex":[0.9991266,0.00003978195,0.000373614,0.000107112,0.0001897442,0.0001631595],"domain_scores_gemma":[0.9990143,0.00001772916,0.000374657,0.0002627087,0.0002675663,0.00006303268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002714447,0.0001034405,0.00008854781,0.00002189049,0.0001222171,0.000002325912,0.00006283453,0.0000251464,0.9931092,0.00001604872,0.00423583,0.001941064],"study_design_scores_gemma":[0.001099684,0.0003522503,0.0001290897,0.00004690147,0.00006095614,0.00005948357,0.0001174164,0.00001881595,0.9886074,0.00006980044,0.009321787,0.0001163967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912484,0.007640995,0.0001620557,0.0002808616,0.0001785631,0.000056591,0.00004336355,0.000003079175,0.0003861305],"genre_scores_gemma":[0.9936438,0.005209746,0.00005246205,0.0001087044,0.0003877923,8.537737e-7,0.00006649047,0.00001242903,0.0005177729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005085958,"threshold_uncertainty_score":0.4057269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144825672940732,"score_gpt":0.2488333230339013,"score_spread":0.2343507557398281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}