{"id":"W2114960004","doi":"10.1093/oxfordjournals.jbchem.a003237","title":"Epitope Distribution of Randomly Established Monoclonal Antibodies against Human Type II DNA Topoisomerases","year":2002,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Epitope; Monoclonal antibody; Topoisomerase; Molecular biology; Antibody; Epitope mapping; DNA; Antigen; Biology; Linear epitope; Chemistry; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002437868,0.000204543,0.0001325132,0.0002732268,0.000154633,0.0002812875,0.0002382785,0.0002302513,0.0009956463],"category_scores_gemma":[0.0004009481,0.0001939839,0.0001490698,0.0002095156,0.0001521029,0.0001715275,0.000196054,0.0004309371,0.0002898224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002933692,"about_ca_system_score_gemma":0.0001316974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918048,"about_ca_topic_score_gemma":0.0006042251,"domain_scores_codex":[0.9997545,0.00004961449,0.00002770895,0.00006930619,0.00005029204,0.00004864808],"domain_scores_gemma":[0.9996862,0.0001156655,0.00004172481,0.0000406477,0.00006084951,0.00005482421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008851052,0.00001712896,0.0005592106,0.0000332325,0.000009104592,0.00002553171,0.00001732468,0.000062969,0.9964024,0.0001727711,0.00003589426,0.00257592],"study_design_scores_gemma":[0.00006409077,0.0006186634,0.01449324,0.00002774902,0.0001075556,0.0006282097,0.00006368469,0.002032344,0.9771075,0.0002737758,0.004571331,0.00001183211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777763,0.002827714,0.01621909,0.00006559071,0.000040181,0.00002718025,0.0001341395,0.00005641448,0.002853291],"genre_scores_gemma":[0.9856043,0.001571512,0.01087915,0.00004818573,0.0000250597,0.0000435473,0.0003859501,0.00001973939,0.00142257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009956463,"threshold_uncertainty_score":0.003330708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144825672940732,"score_gpt":0.2488333230339013,"score_spread":0.2343507557398281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}