{"id":"W2114973994","doi":"10.1002/anie.201405990","title":"Forazoline A: Marine‐Derived Polyketide with Antifungal In Vivo Efficacy","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; Great Lakes Bioenergy Research Center; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; University of Wisconsin-Madison; U.S. Public Health Service; Office of Science; U.S. Department of Agriculture; U.S. Department of Energy; National Institutes of Health; National Science Foundation","keywords":"Polyketide; Antifungal; Natural product; Yeast; In vivo; Metabolomics; Computational biology; Biology; Marine invertebrates; Bacteria; Candida albicans; Chemistry; Stereochemistry; Microbiology; Biochemistry; Genetics; Gene; Bioinformatics; Biosynthesis; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345055,0.0004875078,0.0002264996,0.0003173756,0.0001433845,0.0003280284,0.0002170126,0.0003153599,0.001860741],"category_scores_gemma":[0.0001670255,0.00006387517,0.0002009861,0.000201783,0.0001978385,0.0002487736,0.0001983723,0.0003901538,0.0002959693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002953753,"about_ca_system_score_gemma":0.0003773576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271466,"about_ca_topic_score_gemma":0.0007334086,"domain_scores_codex":[0.9999317,0.00001651437,0.000007125102,0.0000143216,0.000009157419,0.00002119019],"domain_scores_gemma":[0.9998657,0.00002164853,0.00003379349,0.00001850655,0.00001593987,0.00004436597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009623375,0.00009660362,0.0003016804,0.0001376897,0.00001332614,0.0001872687,0.00001949517,0.0003159826,0.990514,0.0001306679,0.0001660589,0.007154817],"study_design_scores_gemma":[0.0002342897,0.005600391,0.003687572,0.00002886014,0.00005558048,0.0006662097,0.00003385232,0.0005767511,0.983933,0.00009041534,0.005071556,0.00002166914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894131,0.004000887,0.001597476,0.0001960604,0.00004697737,0.00009095638,0.00157816,0.0001941986,0.002882218],"genre_scores_gemma":[0.9948673,0.001275926,0.001458474,0.00007656225,0.000007870312,0.00003909653,0.0007750978,0.00001414975,0.001485605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860741,"threshold_uncertainty_score":0.006224811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009792198579965236,"score_gpt":0.2418439218278297,"score_spread":0.2320517232478645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}