{"id":"W2115028635","doi":"10.1016/j.ctrv.2010.03.006","title":"Targeting DNA repair in breast cancer: A clinical and translational update","year":2010,"lang":"en","type":"review","venue":"Cancer Treatment Reviews","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"DNA repair; Synthetic lethality; Medicine; Breast cancer; Homologous recombination; Poly ADP ribose polymerase; Cancer research; DNA damage; Genome instability; BRCA2 Protein; DNA mismatch repair; Cancer; DNA; Mutation; Germline mutation; Genetics; Polymerase; Biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008057729,0.0008039926,0.004527322,0.0002099635,0.00007910276,0.00001960213,0.0001258548,0.0005531784,0.001483268],"category_scores_gemma":[0.00002098854,0.0005404011,0.001334817,0.0004296425,0.0002275083,0.000103136,0.00002365742,0.0008100875,0.00008499038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005578561,"about_ca_system_score_gemma":0.001443409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798228,"about_ca_topic_score_gemma":0.0001827096,"domain_scores_codex":[0.9955065,0.0004756184,0.002263747,0.001067543,0.0002470454,0.0004395861],"domain_scores_gemma":[0.9980595,0.0001591266,0.0007901043,0.0006058174,0.00006863511,0.0003168323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000604501,0.0002053855,0.005091145,0.008192714,0.0003185287,0.00003826764,0.00003925909,2.208864e-7,0.000001035951,0.0000205692,0.005239605,0.9807928],"study_design_scores_gemma":[0.002321642,0.00007919638,0.0003760303,0.03652269,0.002096167,0.0001507614,0.000001668852,0.000008346043,5.912937e-7,0.00001486614,0.9580199,0.0004081301],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003637104,0.992262,0.000005432506,0.001446785,0.0007553934,0.003998463,0.001189814,0.00009228378,0.0002134318],"genre_scores_gemma":[0.000001857089,0.9899845,0.0008908445,0.0007560059,0.001828457,0.005630337,0.0004416661,0.0001021512,0.0003641794],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9803847,"threshold_uncertainty_score":0.9997048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208981374419015,"score_gpt":0.464194918853734,"score_spread":0.3432967814118325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}