{"id":"W2115028635","doi":"10.1016/j.ctrv.2010.03.006","title":"Targeting DNA repair in breast cancer: A clinical and translational update","year":2010,"lang":"en","type":"review","venue":"Cancer Treatment Reviews","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"DNA repair; Synthetic lethality; Medicine; Breast cancer; Homologous recombination; Poly ADP ribose polymerase; Cancer research; DNA damage; Genome instability; BRCA2 Protein; DNA mismatch repair; Cancer; DNA; Mutation; Germline mutation; Genetics; Polymerase; Biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001173844,0.001279357,0.002525352,0.002208843,0.0002825667,0.001293181,0.001205386,0.001552212,0.003663127],"category_scores_gemma":[0.001198671,0.0004277996,0.000767053,0.002640042,0.0004800356,0.001594784,0.0006822967,0.002888507,0.002322204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000732489,"about_ca_system_score_gemma":0.001522382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496733,"about_ca_topic_score_gemma":0.004154819,"domain_scores_codex":[0.9997599,0.00004310102,0.00003737389,0.00003635657,0.00009938837,0.000023814],"domain_scores_gemma":[0.9992744,0.000340798,0.0001050204,0.00001448067,0.0002085904,0.00005669732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002103092,0.0001299037,0.0001715603,0.01821519,0.0001671088,0.0001868313,0.00004088127,0.0004139045,0.002297294,0.001233729,0.06441596,0.9125174],"study_design_scores_gemma":[0.000128691,0.0002763761,0.0008798349,0.00380566,0.000509894,0.001139323,0.00005360861,0.0002210859,0.0006858578,0.0009033969,0.9913652,0.00003103119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007577286,0.9988055,0.0001153103,0.0003337193,0.0002138804,0.000007166074,0.00002259048,0.00000892113,0.0004170738],"genre_scores_gemma":[0.0003630113,0.9985411,0.0002185174,0.0002990016,0.0001846582,0.000007073483,0.00003396153,0.000001432648,0.0003513168],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003663127,"threshold_uncertainty_score":0.01225436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208981374419015,"score_gpt":0.464194918853734,"score_spread":0.3432967814118325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}