{"id":"W2115031069","doi":"10.1124/jpet.106.103382","title":"Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":380,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"Cardinal Health","keywords":"Microdialysis; Reuptake; Reuptake inhibitor; Chemistry; Pharmacology; Serotonin; Norepinephrine transporter; Serotonin Uptake Inhibitors; Serotonin transporter; Serotonin reuptake inhibitor; IC50; In vivo; Venlafaxine; Dopamine; Transporter; Endocrinology; Internal medicine; In vitro; Extracellular; Receptor; Biology; Medicine; Biochemistry; Fluoxetine; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360103,0.0003292371,0.0005021644,0.0002499767,0.0001782683,0.0002253085,0.0003613828,0.0003902425,0.001470811],"category_scores_gemma":[0.0001380159,0.00009305785,0.0001626333,0.0001823171,0.0001660929,0.0002217024,0.0001216597,0.0006502052,0.0005018261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003479701,"about_ca_system_score_gemma":0.0002967997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000938368,"about_ca_topic_score_gemma":0.00417363,"domain_scores_codex":[0.9999419,0.00001187917,0.000007967088,0.00001065972,0.00001420206,0.00001332269],"domain_scores_gemma":[0.9999578,0.000006902418,0.00001175055,0.00000267088,0.000005249251,0.00001554953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0102966,0.0008419191,0.004092718,0.0009271415,0.0002457657,0.003670957,0.0001463195,0.0008689933,0.4812143,0.00363682,0.009570222,0.4844883],"study_design_scores_gemma":[0.01436296,0.038339,0.06043656,0.0002602476,0.0007792621,0.04210887,0.0002597004,0.004756378,0.3493787,0.001543154,0.487618,0.0001570817],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8611209,0.1103272,0.006253619,0.003663518,0.0007590716,0.0002342444,0.0009724264,0.0003780911,0.01629093],"genre_scores_gemma":[0.9196509,0.05635101,0.004809427,0.001086817,0.0002323987,0.00008484744,0.001376772,0.00002695013,0.01638082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470811,"threshold_uncertainty_score":0.004920304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351040810139968,"score_gpt":0.333431351749316,"score_spread":0.2999209436479163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}