{"id":"W2115050101","doi":"10.1021/bi035643g","title":"Structure-Based Design of an Indolicidin Peptide Analogue with Increased Protease Stability<sup>,</sup>","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protease; Circular dichroism; Peptide; Chemistry; Trypsin; Phospholipid; Membrane; Stereochemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060119,0.0002853411,0.0001959165,0.0001073682,0.0001005707,0.0003101468,0.0003848198,0.0003670968,0.0009377559],"category_scores_gemma":[0.0001506596,0.0001217307,0.0001836647,0.0001279945,0.000155243,0.0001822503,0.0001290987,0.0003759674,0.0002371314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328599,"about_ca_system_score_gemma":0.0001852985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546618,"about_ca_topic_score_gemma":0.0003959966,"domain_scores_codex":[0.9999256,0.00001433331,0.000009454341,0.00001553741,0.00001699188,0.00001802964],"domain_scores_gemma":[0.9998856,0.00001556458,0.00004662741,0.000007045543,0.00002003193,0.00002513662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003019979,0.00007650732,0.0001500527,0.0000695218,0.00001021829,0.0001107484,0.00001295362,0.000785662,0.9942181,0.000139799,0.00006770324,0.004056701],"study_design_scores_gemma":[0.0001774326,0.001884106,0.00129054,0.000008518195,0.00004591272,0.0003897356,0.00001894821,0.002717976,0.9891562,0.00003452485,0.004263528,0.00001260916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940713,0.0008955193,0.003100215,0.00009980436,0.00002845249,0.0001162098,0.0001805687,0.00004307253,0.001464908],"genre_scores_gemma":[0.9871321,0.0007107499,0.01028709,0.00009982346,0.00001256601,0.0000659991,0.0004199599,0.00001742582,0.001254252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009377559,"threshold_uncertainty_score":0.003137112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236465026095337,"score_gpt":0.206736021159776,"score_spread":0.1943713708988227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}