{"id":"W2115053548","doi":"10.1095/biolreprod67.2.370","title":"Endocrine Alterations and Signaling Changes Associated with Declining Ovarian Function and Advanced Biological Aging in Follicle-Stimulating Hormone Receptor Haploinsufficient Mice1","year":2002,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Internal medicine; Endocrinology; Biology; Haploinsufficiency; Follicle-stimulating hormone; Ovary; Ovulation; Hormone; Endocrine system; Gonadotropin; Follicle-stimulating hormone receptor; Luteinizing hormone; Testosterone (patch); Gene; Phenotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002847713,0.0001173843,0.0001610996,0.00007780563,0.0001038686,0.000007428343,0.00002845318,0.0001412504,0.000003054749],"category_scores_gemma":[0.0002689536,0.00009649768,0.00001858766,0.0001317853,0.0001173395,0.000007520722,0.0000361787,0.0001074962,4.148694e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107034,"about_ca_system_score_gemma":0.000005620152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001181338,"about_ca_topic_score_gemma":0.000009624881,"domain_scores_codex":[0.9990324,0.0001147765,0.0001874121,0.0004603942,0.00003731794,0.0001677271],"domain_scores_gemma":[0.9996109,0.00003694321,0.0001396353,0.0001250823,0.0000540627,0.00003339573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001297216,0.00007163881,0.02068464,0.000005474147,0.00004779277,7.635192e-7,0.00008675914,0.000412482,0.9633812,0.00003428134,0.000008676065,0.01513659],"study_design_scores_gemma":[0.007051679,0.01523186,0.07167318,0.0002302707,0.0001273848,0.0001561876,0.0006625725,0.00523169,0.8957772,0.0001637193,0.002847595,0.0008466652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883865,0.01035635,0.0005468368,0.0003756563,0.00009220735,0.0001969724,0.000004029092,0.00002030287,0.0000211324],"genre_scores_gemma":[0.9969947,0.001225163,0.001498167,0.0000239867,0.0001067,0.00001659809,0.00009718551,0.000009722005,0.00002779841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06760399,"threshold_uncertainty_score":0.3935061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941806263865346,"score_gpt":0.245701169543117,"score_spread":0.2262831069044635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}