{"id":"W2115053548","doi":"10.1095/biolreprod67.2.370","title":"Endocrine Alterations and Signaling Changes Associated with Declining Ovarian Function and Advanced Biological Aging in Follicle-Stimulating Hormone Receptor Haploinsufficient Mice1","year":2002,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Internal medicine; Endocrinology; Biology; Haploinsufficiency; Follicle-stimulating hormone; Ovary; Ovulation; Hormone; Endocrine system; Gonadotropin; Follicle-stimulating hormone receptor; Luteinizing hormone; Testosterone (patch); Gene; Phenotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002204539,0.0006493769,0.0004132884,0.0008442726,0.0001677752,0.000298316,0.000280269,0.0004403608,0.001694983],"category_scores_gemma":[0.0002122532,0.0003563924,0.0003825894,0.0001839071,0.0003661095,0.0002233218,0.0001959024,0.0007189685,0.0003490073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842513,"about_ca_system_score_gemma":0.0001198278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004225119,"about_ca_topic_score_gemma":0.0006329683,"domain_scores_codex":[0.9998488,0.00001479809,0.0000201399,0.00004902696,0.00003802794,0.00002908535],"domain_scores_gemma":[0.9995035,0.00003963238,0.0002441451,0.00003794812,0.00003734935,0.0001374685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636533,0.0000195488,0.001325249,0.00001464879,0.00000658811,0.0001591871,0.000015197,0.00001796366,0.9975669,0.00002806038,0.00002829373,0.000654728],"study_design_scores_gemma":[0.00008728999,0.001501817,0.2724175,0.00002472327,0.0001257207,0.005393407,0.0001688685,0.0008261917,0.7165456,0.0001651625,0.002707591,0.00003604728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960524,0.001211383,0.001301347,0.00006517006,0.00002695975,0.00001429082,0.0007974004,0.00009737974,0.0004337529],"genre_scores_gemma":[0.9873653,0.001873115,0.003057271,0.0001469619,0.00004732431,0.00006164224,0.001933074,0.0001077609,0.005407514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694983,"threshold_uncertainty_score":0.005670249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941806263865346,"score_gpt":0.245701169543117,"score_spread":0.2262831069044635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}