{"id":"W2115054742","doi":"10.1158/0008-5472.can-08-4425","title":"Transcript Level Modulates the Inherent Oncogenicity of RET/PTC Oncoproteins","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; Queen's University","funders":"","keywords":"Cancer research; Proto-Oncogene Proteins c-ret; Medullary thyroid cancer; Biology; Fusion gene; RET proto-oncogene; Oncogene; Fusion protein; Carcinogenesis; Mutation; Cancer; Gene; Thyroid cancer; Genetics; Cell cycle; Receptor; Recombinant DNA; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081706,0.0001386437,0.0001612042,0.000221217,0.0001755223,0.000508384,0.0001015279,0.0002410001,0.001107702],"category_scores_gemma":[0.0002483366,0.000138986,0.0001778872,0.0001684869,0.0002116209,0.0002181975,0.0001987758,0.0003709767,0.0003712826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264834,"about_ca_system_score_gemma":0.0001756809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659204,"about_ca_topic_score_gemma":0.001052315,"domain_scores_codex":[0.9998054,0.00002295859,0.00001421307,0.00005747797,0.00004485872,0.00005514176],"domain_scores_gemma":[0.9998063,0.00005334344,0.00004350287,0.00002028049,0.00004016656,0.00003642303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005370528,0.000007146997,0.0003247233,0.00001117579,0.000002202567,0.00002352905,0.00001227246,0.00001807536,0.9991455,0.00005719269,0.00002471613,0.0003197155],"study_design_scores_gemma":[0.00001181963,0.0002496929,0.03537839,0.000008071384,0.00003065433,0.0004045891,0.0001245617,0.001194111,0.9593894,0.0001204288,0.003079815,0.000008483937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937339,0.001559478,0.001753621,0.0001417754,0.00003680278,0.00001307599,0.0007255247,0.00005909977,0.001976629],"genre_scores_gemma":[0.9953602,0.0006332655,0.0008383038,0.00005504076,0.00001566963,0.00002224709,0.001140914,0.00002206567,0.001912431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107702,"threshold_uncertainty_score":0.003705621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2372133478102012,"score_gpt":0.4517700918389119,"score_spread":0.2145567440287107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}