{"id":"W2115054742","doi":"10.1158/0008-5472.can-08-4425","title":"Transcript Level Modulates the Inherent Oncogenicity of RET/PTC Oncoproteins","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; Queen's University","funders":"","keywords":"Cancer research; Proto-Oncogene Proteins c-ret; Medullary thyroid cancer; Biology; Fusion gene; RET proto-oncogene; Oncogene; Fusion protein; Carcinogenesis; Mutation; Cancer; Gene; Thyroid cancer; Genetics; Cell cycle; Receptor; Recombinant DNA; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005346965,0.0001360009,0.0003068532,0.0001001975,0.0001467938,0.00001908001,0.0002209308,0.00007653235,0.0004494493],"category_scores_gemma":[0.00005021189,0.00008260189,0.0001544381,0.0004390091,0.0002082162,0.00004719669,0.00002947131,0.0004253218,0.00002021235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006041676,"about_ca_system_score_gemma":0.0005645734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003390064,"about_ca_topic_score_gemma":0.0006516466,"domain_scores_codex":[0.9980612,0.0001176132,0.0002622137,0.0003024067,0.0008211598,0.0004354304],"domain_scores_gemma":[0.9988343,0.00008583652,0.00004861887,0.0005352317,0.0003340159,0.0001620135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001959213,0.002380403,0.01381264,0.0002875051,0.000584363,0.0001103812,0.003907715,0.000134407,0.5294005,0.003645126,0.03429063,0.4094871],"study_design_scores_gemma":[0.003397104,0.002448773,0.2298966,0.0005104548,0.0001089127,0.00001271262,0.0003301775,0.00005339025,0.7321752,0.001749418,0.02915671,0.0001605009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963274,0.01329208,0.00002529457,0.01960422,0.00008938419,0.00116473,0.00006846023,0.00002406772,0.002457753],"genre_scores_gemma":[0.9947803,0.002917427,0.00008337404,0.0003499039,0.0002323957,0.0003182176,0.000007383955,0.00001708704,0.001293884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4093266,"threshold_uncertainty_score":0.5124785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2372133478102012,"score_gpt":0.4517700918389119,"score_spread":0.2145567440287107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}