{"id":"W2115077956","doi":"10.1186/1475-2840-12-134","title":"Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells","year":2013,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute; University of Saskatchewan","funders":"Canadian Institutes of Health Research; China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Methylglyoxal; Endothelial nitric oxide synthase; Medicine; Nitric oxide; Nitric oxide synthase; Angiology; Nitric Oxide Synthase Type III; Endothelial dysfunction; Pharmacology; Diabetes mellitus; Internal medicine; Cell biology; Biochemistry; Endocrinology; Enos; Chemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370218,0.0003395941,0.0003352088,0.0001657893,0.0001264362,0.0002200543,0.0001997402,0.000210239,0.0006906122],"category_scores_gemma":[0.000100507,0.00009727157,0.0003088568,0.0001991159,0.0001576899,0.000164359,0.0001425331,0.0004794172,0.0002371215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341676,"about_ca_system_score_gemma":0.00009054965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565611,"about_ca_topic_score_gemma":0.0004315758,"domain_scores_codex":[0.9998205,0.00004185736,0.00002391344,0.00002994031,0.00003917493,0.00004458821],"domain_scores_gemma":[0.9999123,0.00001351328,0.00002862333,0.00001231351,0.00001155895,0.00002175176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003065916,0.00008277558,0.0002226092,0.0000375426,0.000008076087,0.00005468419,0.00001379536,0.00002537037,0.9984406,0.00003217028,0.00002894895,0.0007468811],"study_design_scores_gemma":[0.00006120877,0.001318357,0.01199424,0.00001068774,0.00004562008,0.0002960335,0.00005068005,0.0009813386,0.9836287,0.00004695478,0.001559481,0.000006729866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942796,0.003127316,0.001279598,0.000119085,0.00004076073,0.00001567573,0.0002800927,0.00004599446,0.0008118521],"genre_scores_gemma":[0.9956305,0.001463712,0.001326576,0.00009075316,0.00002344533,0.00003320897,0.0005165602,0.00001005334,0.0009050861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006906122,"threshold_uncertainty_score":0.002310336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097701450278542,"score_gpt":0.237756101505265,"score_spread":0.2267790870024796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}