{"id":"W2115078134","doi":"10.1200/jco.2014.58.3922","title":"<i>BRAF</i> Mutation and <i>CDKN2A</i> Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Pediatric Oncology Group; University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Hospital for Sick Children; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"CDKN2A; Medicine; Glioma; V600E; Oncology; Cancer research; Exome sequencing; Internal medicine; Mutation; Biology; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003571786,0.0001824751,0.001715054,0.0001673581,0.00003217598,0.00001094969,0.0001113845,0.0004050415,0.00004340207],"category_scores_gemma":[0.004815707,0.0001279176,0.0004369132,0.0001995691,0.0002818292,0.0001351415,0.00006186245,0.0006939482,0.0000103156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009378298,"about_ca_system_score_gemma":0.001224969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005122267,"about_ca_topic_score_gemma":0.00005538334,"domain_scores_codex":[0.9952962,0.0004574991,0.003316793,0.0002460457,0.0004685277,0.0002148646],"domain_scores_gemma":[0.9934096,0.002484866,0.002573519,0.0002061993,0.0006532873,0.0006725388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008243833,0.02298296,0.5171748,0.0001170644,0.001462333,0.006060972,0.0004095146,0.00002542291,0.001088454,0.0007997365,0.01216929,0.4294657],"study_design_scores_gemma":[0.03859646,0.0396074,0.9041063,0.0001774506,0.001230118,0.00351177,0.0001337312,0.00004306521,0.0007299299,0.002779275,0.008937063,0.0001474162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883081,0.001269312,0.0001266426,0.008403177,0.0008441695,0.0002443468,0.00001492643,0.00001211075,0.0007772527],"genre_scores_gemma":[0.9917082,0.0003529884,0.005622704,0.001442461,0.0008139721,0.000006143976,0.00002355431,0.00002067673,0.000009289309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4293182,"threshold_uncertainty_score":0.5765199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06472120420027387,"score_gpt":0.3951022263921589,"score_spread":0.330381022191885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}