{"id":"W2115084586","doi":"10.1101/gad.248369.114","title":"Nuclear position dictates DNA repair pathway choice","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Advanced Science Institute; National Cancer Institute; RIKEN; National Institutes of Health; French Infrastructure for Integrated Structural Biology; University of California, San Francisco; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Genentech; Fondation Schlumberger pour l’Education et la Recherche; Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Association pour la Recherche sur le Cancer","keywords":"Biology; DNA repair; Cell biology; Homologous recombination; DNA damage; DNA; Nuclear DNA; Nuclear lamina; Cell nucleus; Genetics; Nucleus; Nuclear protein; Gene; Mitochondrial DNA; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227895,0.0001677302,0.0001150729,0.00003442131,0.0001349902,0.00002282768,0.0001634784,0.0001188673,0.00004560282],"category_scores_gemma":[0.00003823821,0.0001647953,0.00007687282,0.00005361834,0.00002397079,0.000003770017,0.0001622726,0.00004279971,0.0001569277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000313971,"about_ca_system_score_gemma":0.00006795912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005078849,"about_ca_topic_score_gemma":0.00001734957,"domain_scores_codex":[0.9989099,0.00005460371,0.00021145,0.0003934864,0.0001638809,0.0002667001],"domain_scores_gemma":[0.9994421,0.000007638229,0.00006381828,0.0003275198,0.00006298028,0.00009596346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001887105,0.00004596152,0.0007622461,0.00001689301,0.00005429898,0.000002257351,0.0001017244,0.000009913523,0.9609174,0.0003046607,0.001358834,0.03640701],"study_design_scores_gemma":[0.0001742763,0.00009182311,0.003647536,0.000009887707,0.000005707935,0.000009717472,0.00002054856,0.00005266687,0.5963224,0.00006259354,0.3994287,0.0001742463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959246,0.0002808911,0.00128057,0.00009917861,0.0002589703,0.0001509896,0.000002655286,0.000127221,0.001874906],"genre_scores_gemma":[0.9712621,0.00006782495,0.02607,0.0008801068,0.0002597991,0.00004151139,0.0001856366,0.00004871285,0.00118433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3980698,"threshold_uncertainty_score":0.6720157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005912873710684227,"score_gpt":0.2048999435577056,"score_spread":0.1989870698470214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}