{"id":"W2115084586","doi":"10.1101/gad.248369.114","title":"Nuclear position dictates DNA repair pathway choice","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Advanced Science Institute; National Cancer Institute; RIKEN; National Institutes of Health; French Infrastructure for Integrated Structural Biology; University of California, San Francisco; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Genentech; Fondation Schlumberger pour l’Education et la Recherche; Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Association pour la Recherche sur le Cancer","keywords":"Biology; DNA repair; Cell biology; Homologous recombination; DNA damage; DNA; Nuclear DNA; Nuclear lamina; Cell nucleus; Genetics; Nucleus; Nuclear protein; Gene; Mitochondrial DNA; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002845676,0.0001809089,0.0002629729,0.0001731623,0.0001674767,0.001005045,0.0002582695,0.0003083322,0.001536616],"category_scores_gemma":[0.0005119606,0.0002768248,0.0001416088,0.0001127733,0.0004235481,0.0006184042,0.0003724583,0.0003905311,0.0008021211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082888,"about_ca_system_score_gemma":0.0002358971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003070588,"about_ca_topic_score_gemma":0.0007429807,"domain_scores_codex":[0.9996594,0.00005022175,0.00002279294,0.0001344434,0.00008851736,0.00004465622],"domain_scores_gemma":[0.9995054,0.0001303724,0.0001398919,0.00007300119,0.00006606288,0.00008527569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007594531,0.00001039628,0.001115325,0.00001770801,0.0000019612,0.00004105789,0.00002039214,0.0001887736,0.9967309,0.0004464348,0.00001929003,0.001331668],"study_design_scores_gemma":[0.00001555068,0.0001922027,0.02471391,0.00001611454,0.00001293107,0.0003425435,0.0001843012,0.004210732,0.9678984,0.0005961771,0.001791738,0.00002539126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989584,0.0008669562,0.00720621,0.00009381512,0.0000187122,0.000009780375,0.0001152887,0.00007034768,0.002034724],"genre_scores_gemma":[0.9962564,0.0004836774,0.002007743,0.00002552025,0.000004227114,0.000007292349,0.00009547008,0.00002541436,0.001094294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536616,"threshold_uncertainty_score":0.005140483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005912873710684227,"score_gpt":0.2048999435577056,"score_spread":0.1989870698470214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}