{"id":"W2115106388","doi":"10.1371/journal.pone.0058618","title":"SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians","year":2013,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Medical Research Council; Hersenstichting; Universitat de Barcelona; Howard Hughes Medical Institute; Eisai; Eli Lilly and Company; Alzheimer's Research Trust; Northern California Institute for Research and Education; National Cancer Institute; Stichting MS Research; Alzheimer's Disease Neuroimaging Initiative; Medpace; National Center for Research Resources; F. Hoffmann-La Roche; Japan Society for the Promotion of Science; GlaxoSmithKline; Pfizer; Ministry of Education, Culture, Sports, Science and Technology; Novartis; Elan; Newcastle University; Office of Research and Development; U.S. Department of Veterans Affairs; Wellcome Trust; Synarc; Dana Foundation; Alzheimer's Association; North Bristol NHS Trust; Bristol-Myers Squibb; AstraZeneca","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Biology; Genetics; Genetic association; SNP; Allele; Alzheimer's disease; Allele frequency; Disease; Genotype; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001291233,0.0006556846,0.002131718,0.0003310397,0.00008476916,0.00006809944,0.0001685993,0.0003021963,0.0004932401],"category_scores_gemma":[0.0001693226,0.0004569026,0.0002268916,0.0004697574,0.000262508,0.00007400905,0.000106565,0.0005824661,0.0004142197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711857,"about_ca_system_score_gemma":0.001054396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002111754,"about_ca_topic_score_gemma":0.0000748269,"domain_scores_codex":[0.9967358,0.0002409387,0.00052796,0.0007738722,0.0009298051,0.0007916518],"domain_scores_gemma":[0.9972863,0.0002285632,0.000185578,0.0006637574,0.0001736055,0.00146224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001465,0.05505245,0.1856377,0.05111949,0.4199651,0.01649612,0.001123932,3.381054e-7,0.000001534789,0.00002252908,0.003359622,0.2657562],"study_design_scores_gemma":[0.02145482,0.005886435,0.1415212,0.3173844,0.4786172,0.0002201655,0.0001813396,0.0005471061,0.00002734002,0.0003079215,0.02790192,0.005950191],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02108675,0.9733688,8.021302e-8,0.0002784352,0.0000076841,0.003529806,0.0009271363,0.00007464362,0.0007266181],"genre_scores_gemma":[0.01196702,0.9844809,0.0001234264,0.0001274382,0.00006322889,0.0008743013,0.001690455,0.0001561265,0.0005170965],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2662649,"threshold_uncertainty_score":0.9997883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1141882522283364,"score_gpt":0.3286495983910006,"score_spread":0.2144613461626642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}