{"id":"W2115106388","doi":"10.1371/journal.pone.0058618","title":"SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians","year":2013,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Medical Research Council; Hersenstichting; Universitat de Barcelona; Howard Hughes Medical Institute; Eisai; Eli Lilly and Company; Alzheimer's Research Trust; Northern California Institute for Research and Education; National Cancer Institute; Stichting MS Research; Alzheimer's Disease Neuroimaging Initiative; Medpace; National Center for Research Resources; F. Hoffmann-La Roche; Japan Society for the Promotion of Science; GlaxoSmithKline; Pfizer; Ministry of Education, Culture, Sports, Science and Technology; Novartis; Elan; Newcastle University; Office of Research and Development; U.S. Department of Veterans Affairs; Wellcome Trust; Synarc; Dana Foundation; Alzheimer's Association; North Bristol NHS Trust; Bristol-Myers Squibb; AstraZeneca","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Biology; Genetics; Genetic association; SNP; Allele; Alzheimer's disease; Allele frequency; Disease; Genotype; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006264127,0.0005926106,0.0004608856,0.0009714007,0.0005438604,0.0006465581,0.0003146029,0.0003744726,0.001865912],"category_scores_gemma":[0.0009752268,0.0003161655,0.0005861681,0.0007903422,0.0004084068,0.0002347304,0.0006110977,0.0003299086,0.0002952615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525344,"about_ca_system_score_gemma":0.0001930798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007587614,"about_ca_topic_score_gemma":0.008896533,"domain_scores_codex":[0.9997011,0.0000485551,0.0000438397,0.0001203675,0.00003793532,0.0000482625],"domain_scores_gemma":[0.9994004,0.00008133811,0.0002035606,0.00005301592,0.00008474716,0.000176929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001364098,0.00008133611,0.9761154,0.00005591402,0.0002294531,0.001109317,0.001128483,0.00005312799,0.0143478,0.0000829779,0.0001883653,0.005243712],"study_design_scores_gemma":[0.00005395248,0.0001647878,0.9972001,0.00001089374,0.0001148766,0.0009839303,0.0005747795,0.00013889,0.0003013343,0.00006421022,0.0003807838,0.00001146802],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9994672,0.0001501456,0.00006891677,0.00001982283,0.000003314937,0.000004546564,0.0001028271,0.000002923553,0.0001804326],"genre_scores_gemma":[0.9988536,0.0001689728,0.0002241585,0.00004006863,0.000007747947,0.000009849354,0.0003170395,0.000007856245,0.0003707893],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007587614,"threshold_uncertainty_score":0.01508689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1141882522283364,"score_gpt":0.3286495983910006,"score_spread":0.2144613461626642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}