{"id":"W2115150571","doi":"10.1006/mcne.2000.0838","title":"Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); University of Ottawa","funders":"Medical Research Council","keywords":"Biology; Camptothecin; Apoptosis; Caspase; Programmed cell death; Caspase 3; DNA fragmentation; Cell biology; DNA damage; Cytochrome c; Caspase-9; Neuroscience; Molecular biology; DNA; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003269167,0.0004781612,0.0003603809,0.0006602401,0.0003666047,0.0004156041,0.0003278418,0.000569783,0.001315132],"category_scores_gemma":[0.0004734839,0.0001550487,0.0005483613,0.0003848787,0.0003975665,0.0005462577,0.0002290387,0.0008489043,0.0002716406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007705303,"about_ca_system_score_gemma":0.0005064763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008100662,"about_ca_topic_score_gemma":0.0007757235,"domain_scores_codex":[0.9998195,0.00002906029,0.00001722784,0.00001771838,0.00003990562,0.00007658535],"domain_scores_gemma":[0.9998094,0.0000370811,0.00004806993,0.00002765256,0.00004122656,0.00003656224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002160606,0.00008286461,0.0008355152,0.0001991184,0.00003064017,0.00074296,0.00007359483,0.0001898679,0.9908861,0.0006908681,0.00007699091,0.004030968],"study_design_scores_gemma":[0.0001094578,0.0003918847,0.01166799,0.00002290292,0.00005004069,0.001582833,0.0001137159,0.001416271,0.9828302,0.001028331,0.0007727497,0.00001371203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880634,0.005888547,0.003519475,0.0002230175,0.00004395967,0.00003105967,0.0002820792,0.00009547218,0.001853045],"genre_scores_gemma":[0.9967266,0.001423184,0.0009896345,0.00003428742,0.000008064115,0.00001703131,0.0001503157,0.000007345297,0.0006435816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315132,"threshold_uncertainty_score":0.005590558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008398779542027512,"score_gpt":0.2183748348842451,"score_spread":0.2099760553422176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}