{"id":"W2115150571","doi":"10.1006/mcne.2000.0838","title":"Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); University of Ottawa","funders":"Medical Research Council","keywords":"Biology; Camptothecin; Apoptosis; Caspase; Programmed cell death; Caspase 3; DNA fragmentation; Cell biology; DNA damage; Cytochrome c; Caspase-9; Neuroscience; Molecular biology; DNA; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436705,0.0001213818,0.000147319,0.00004591372,0.0000404447,0.00001036848,0.000144252,0.00006911403,0.00001970753],"category_scores_gemma":[0.00002785974,0.0001163828,0.00005532443,0.0001405743,0.000161502,0.000005376216,0.00006391603,0.00006752653,5.355752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004133325,"about_ca_system_score_gemma":0.00002910907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003673003,"about_ca_topic_score_gemma":0.00000404689,"domain_scores_codex":[0.9989246,0.0000816769,0.0002485442,0.0003570947,0.0001906918,0.0001974587],"domain_scores_gemma":[0.9995601,0.000005702812,0.00005834438,0.0002686344,0.00002408209,0.00008319038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002369933,0.0001240237,0.0005517152,0.00002096229,0.000001754525,0.00001998899,0.00002128973,0.0002999163,0.9978941,0.0003041885,0.000009665407,0.0007286813],"study_design_scores_gemma":[0.0003858418,0.0003646648,0.004306881,0.00001105347,0.00001256257,0.00000562928,0.00001197008,0.002148845,0.992003,0.0001045949,0.0005321656,0.0001127695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995805,0.0003769164,0.003286983,0.00003152456,0.00004555658,0.0001633919,0.0000100099,0.000003415722,0.0002772616],"genre_scores_gemma":[0.9993238,0.000152635,0.0001010957,0.0001391418,0.000006190759,0.000004633704,0.00002425732,0.0000114905,0.0002367607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005891094,"threshold_uncertainty_score":0.4745951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008398779542027512,"score_gpt":0.2183748348842451,"score_spread":0.2099760553422176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}