{"id":"W2115170131","doi":"10.4049/jimmunol.1102042","title":"Overexpression of the CTLA-4 Isoform Lacking Exons 2 and 3 Causes Autoimmunity","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Wellcome Trust","keywords":"Autoimmunity; Gene isoform; T cell; Biology; Cell biology; CTLA-4; Genetically modified mouse; FOXP3; Exon; Immune system; Molecular biology; Transgene; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602859,0.0008771322,0.0004419509,0.0006216312,0.0002132878,0.0002888966,0.0002905994,0.0006421755,0.001449074],"category_scores_gemma":[0.0001792393,0.0003806601,0.0005247811,0.0002984179,0.0003323637,0.000168537,0.0002862326,0.001064922,0.0005057361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004537477,"about_ca_system_score_gemma":0.0002360717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007397326,"about_ca_topic_score_gemma":0.0007522617,"domain_scores_codex":[0.9996839,0.00003803472,0.0000500996,0.00007185127,0.00006473206,0.0000914593],"domain_scores_gemma":[0.9994552,0.00007272098,0.0002061565,0.0000462166,0.00001714832,0.0002025805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002934268,0.00007929799,0.0004892721,0.00002815303,0.00001048626,0.0003720928,0.0000131276,0.0001231946,0.9979729,0.00005940278,0.00006584726,0.0004929708],"study_design_scores_gemma":[0.0002190416,0.001983136,0.03564339,0.00002534329,0.0001247471,0.00534304,0.00008877545,0.003388926,0.9503631,0.0001994499,0.002583434,0.00003762407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979166,0.0002591295,0.0007756018,0.00005100972,0.00003882166,0.00001397191,0.0002600066,0.000170007,0.0005149194],"genre_scores_gemma":[0.9949448,0.0004490239,0.001196195,0.00007016778,0.00003125458,0.00004852386,0.0006218247,0.00005921847,0.002578991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449074,"threshold_uncertainty_score":0.004847646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02613151256949629,"score_gpt":0.2285804976880517,"score_spread":0.2024489851185554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}