{"id":"W2115172250","doi":"10.1124/jpet.107.125526","title":"ST91 [2-(2,6-Diethylphenylamino)-2-imidazoline Hydrochloride]-Mediated Spinal Antinociception and Synergy with Opioids Persists in the Absence of Functional α-2A- or α-2C-Adrenergic Receptors","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute on Drug Abuse","keywords":"Pharmacology; Imidazoline receptor; Agonist; Chemistry; Opioid; Alpha (finance); Analgesic; Antagonist; Alpha-2 adrenergic receptor; Partial agonist; Nociception; Potency; Receptor; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004208212,0.0008853092,0.001295878,0.0004670758,0.0002675443,0.0004509524,0.0008561796,0.0007765368,0.002981707],"category_scores_gemma":[0.0005296867,0.0005560542,0.0006591251,0.0003939297,0.0006436767,0.0006949009,0.0002899183,0.002095379,0.0008843034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004524081,"about_ca_system_score_gemma":0.0008114779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008703446,"about_ca_topic_score_gemma":0.002640403,"domain_scores_codex":[0.9995296,0.00008288642,0.0000432031,0.00004477818,0.0001044303,0.000195127],"domain_scores_gemma":[0.9995971,0.00008553463,0.0001310514,0.00005755166,0.00002884816,0.00009983785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002456826,0.0001706555,0.0001363975,0.0001331488,0.00004225216,0.0002042592,0.00003180994,0.0001135505,0.9920254,0.0002841878,0.0001901346,0.004211313],"study_design_scores_gemma":[0.001105866,0.008353854,0.00807477,0.00004170947,0.00009590229,0.001008268,0.00006819103,0.001572694,0.9775614,0.0001494725,0.001932574,0.00003521265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893789,0.003594176,0.001710975,0.0002939596,0.0001548501,0.0001070884,0.0004885578,0.0002174144,0.004054039],"genre_scores_gemma":[0.9928284,0.001861946,0.001811126,0.0001208171,0.00008312925,0.00007169538,0.000813937,0.00003476839,0.002374222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002981707,"threshold_uncertainty_score":0.009974778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.030826754707839,"score_gpt":0.3346298532580336,"score_spread":0.3038030985501946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}