{"id":"W2115175555","doi":"10.1046/j.1365-2958.2001.02589.x","title":"Topological and functional characterization of WbpM, an inner membrane UDP‐GlcNAc C<sub>6</sub> dehydratase essential for lipopolysaccharide biosynthesis in <i>Pseudomonas aeruginosa</i>","year":2001,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Dehydratase; Biology; Biochemistry; Biosynthesis; Bacterial outer membrane; Transmembrane protein; Transmembrane domain; Complementation; Inner membrane; Mutant; Enzyme; Amino acid; Membrane; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002272056,0.0002642185,0.0003554247,0.0001195668,0.00006459709,0.00001949012,0.0001746853,0.0004233153,0.00002184615],"category_scores_gemma":[0.000104705,0.000258333,0.0001046571,0.0001107148,0.000342637,0.00001472228,0.0001148936,0.00009924279,0.000003136679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001820338,"about_ca_system_score_gemma":0.00005949279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001605815,"about_ca_topic_score_gemma":0.0000689727,"domain_scores_codex":[0.9982929,0.0001814747,0.0004462243,0.0006440324,0.00005455919,0.0003808318],"domain_scores_gemma":[0.9992524,0.00003059365,0.000187685,0.0003481072,0.0001007643,0.0000804035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007297001,0.0001793251,0.003866971,0.00003636357,0.00004623124,0.00002182201,0.00001374372,0.00001121668,0.9941562,0.0003432482,0.00002883805,0.0005662792],"study_design_scores_gemma":[0.0008625885,0.0002957146,0.004868577,0.00001730981,0.00003712691,0.0001433097,0.00001958771,0.00002332237,0.9920636,0.00005881378,0.001333757,0.0002762691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887264,0.0001654864,0.01003991,0.0001955925,0.0001980158,0.0003923326,0.0002515375,0.00001404685,0.00001667383],"genre_scores_gemma":[0.9960802,0.000292422,0.0006829729,0.0004193202,0.000132328,0.00002843669,0.002314638,0.00003302028,0.00001666894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009356934,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006694210271664069,"score_gpt":0.2170967392717616,"score_spread":0.2104025290000975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}