{"id":"W2115175555","doi":"10.1046/j.1365-2958.2001.02589.x","title":"Topological and functional characterization of WbpM, an inner membrane UDP‐GlcNAc C<sub>6</sub> dehydratase essential for lipopolysaccharide biosynthesis in <i>Pseudomonas aeruginosa</i>","year":2001,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Dehydratase; Biology; Biochemistry; Biosynthesis; Bacterial outer membrane; Transmembrane protein; Transmembrane domain; Complementation; Inner membrane; Mutant; Enzyme; Amino acid; Membrane; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136771,0.0003350849,0.0001694284,0.0001665271,0.0001203198,0.0002204228,0.0001704177,0.0001533162,0.0004902441],"category_scores_gemma":[0.0001846715,0.00008745386,0.0002348817,0.0001846178,0.0002189549,0.0002396745,0.0001682562,0.0002478446,0.000282004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361734,"about_ca_system_score_gemma":0.00019046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307963,"about_ca_topic_score_gemma":0.0005964328,"domain_scores_codex":[0.9999356,0.00001008295,0.000006789749,0.00001393416,0.0000203384,0.00001321157],"domain_scores_gemma":[0.9998782,0.00001531036,0.0000333593,0.00001299745,0.00002301992,0.00003716434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003411269,0.000009110569,0.0002875368,0.00002454441,0.000001653996,0.00004223522,0.00001377058,0.00003269485,0.99882,0.00003801331,0.00001193439,0.0006843485],"study_design_scores_gemma":[0.000006774439,0.0001765224,0.02328049,0.000005593874,0.00001408426,0.001021563,0.00008412771,0.0009123423,0.9709608,0.0000642435,0.003465134,0.000008268756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957551,0.0005925503,0.002342969,0.0000682391,0.000009633085,0.00001454799,0.000622062,0.00002126153,0.0005736795],"genre_scores_gemma":[0.9895348,0.0007170558,0.004275065,0.00003849474,0.00001209911,0.00001750892,0.003597031,0.00002441364,0.001783601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307963,"threshold_uncertainty_score":0.002600729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006694210271664069,"score_gpt":0.2170967392717616,"score_spread":0.2104025290000975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}