{"id":"W2115197208","doi":"10.1107/s0907444999016376","title":"Structural study of the complex between human pepsin and a phosphorus-containing peptidic transition-state analog","year":2000,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Medical Council of Canada","funders":"National Cancer Institute","keywords":"Phosphonate; Chemistry; Crystal structure; Stereochemistry; Enzyme; Pepsin; Transition state analog; Hydrolase; Crystallography; Active site; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202297,0.0005909984,0.0008442135,0.0001587238,0.0005341468,0.0006572104,0.001001193,0.0006040141,0.001358159],"category_scores_gemma":[0.0005643067,0.0002597807,0.0003198576,0.0004294008,0.0004421243,0.0003347902,0.0001938193,0.001357619,0.0002260765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001839136,"about_ca_system_score_gemma":0.0007794674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01039267,"about_ca_topic_score_gemma":0.007181603,"domain_scores_codex":[0.9998401,0.00002169115,0.000006874142,0.00004558668,0.00005891932,0.00002676388],"domain_scores_gemma":[0.9998093,0.00006669159,0.00003990742,0.000009479412,0.00002476713,0.0000498623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005806246,0.001567785,0.01292876,0.001296689,0.0007159698,0.007429677,0.001292235,0.04097931,0.8958902,0.007388662,0.005999311,0.01870525],"study_design_scores_gemma":[0.001738434,0.003409771,0.06589005,0.000126937,0.0006245234,0.008582396,0.001409689,0.2331226,0.6530295,0.001915051,0.02983209,0.0003190074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955605,0.001379897,0.001073292,0.0002756151,0.00003891278,0.00001886245,0.0004209811,0.00009965682,0.001132187],"genre_scores_gemma":[0.9923962,0.0008389356,0.002596158,0.0001114303,0.00001244486,0.00001380122,0.002593171,0.00002967983,0.001408102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01039267,"threshold_uncertainty_score":0.02066433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919319481411657,"score_gpt":0.2370653751833498,"score_spread":0.2178721803692332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}