{"id":"W2115216159","doi":"10.1128/aac.49.8.3109-3113.2005","title":"3′,5′-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming <i>Staphylococcus aureus</i> Strains in a Mouse Model of Mastitis Infection","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Biofilm; Staphylococcus aureus; Microbiology; In vivo; Virulence; Mastitis; Bacteria; Pathogen; Staphylococcal infections; Antimicrobial; Antibiotics; In vitro; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791412,0.0004920412,0.0004210687,0.0003394422,0.0001227433,0.000213653,0.0002331312,0.00054482,0.0009775809],"category_scores_gemma":[0.0001838151,0.0002034692,0.0001915869,0.0001171819,0.0002384482,0.000152397,0.0001014337,0.0008432886,0.0002246782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721318,"about_ca_system_score_gemma":0.0002160884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007422232,"about_ca_topic_score_gemma":0.001266829,"domain_scores_codex":[0.9998139,0.00004257276,0.00001488479,0.00002201193,0.00005001178,0.00005664813],"domain_scores_gemma":[0.9998444,0.00002431026,0.00004057024,0.0000121044,0.00001634469,0.00006225914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002905018,0.0001559323,0.00008994985,0.00002776169,0.000004057535,0.00002960565,0.00000672449,0.0000424267,0.9977921,0.0000300888,0.00005326751,0.001477602],"study_design_scores_gemma":[0.0001113437,0.005584663,0.00387626,0.00001455361,0.00002850094,0.0002036104,0.00002237535,0.0007999023,0.9881477,0.00004564276,0.00115882,0.000006631018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958037,0.001483167,0.0007677662,0.0001842428,0.00004740157,0.00003505346,0.0001761872,0.000137589,0.001364957],"genre_scores_gemma":[0.9930437,0.001299747,0.001879631,0.00015549,0.00002426422,0.00004809313,0.0004062832,0.0000295441,0.003113242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009775809,"threshold_uncertainty_score":0.003270328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906540879339677,"score_gpt":0.2693864303609199,"score_spread":0.2503210215675232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}