{"id":"W2115258056","doi":"10.1093/hmg/9.7.1041","title":"Sequential deletion of C-terminal amino acids of the E1alpha component of the pyruvate dehydrogenase (PDH) complex leads to reduced steady-state levels of functional E1alpha2beta2 tetramers: implications for patients with PDH deficiency","year":2000,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Medical Research Council","keywords":"Biology; Pyruvate dehydrogenase complex; Amino acid; Terminal (telecommunication); Biochemistry; Steady state (chemistry); Oxoglutarate dehydrogenase complex; Component (thermodynamics); Lactate dehydrogenase; Enzyme; Pyruvate dehydrogenase phosphatase; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273378,0.0001956116,0.0002573328,0.00004445012,0.0001319126,0.000006481953,0.0004791414,0.00008585804,0.00002502785],"category_scores_gemma":[0.00004970256,0.00013627,0.0002237227,0.0002019268,0.0006968727,0.000003163908,0.0002187404,0.00008750063,3.535605e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002340849,"about_ca_system_score_gemma":0.00009831581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002060884,"about_ca_topic_score_gemma":0.00001801213,"domain_scores_codex":[0.998373,0.0001055526,0.0005228453,0.0003207453,0.0004063947,0.0002714664],"domain_scores_gemma":[0.9983833,0.00001856387,0.0002930784,0.0006355332,0.0006016985,0.00006784663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848122,0.0003628405,0.005631016,0.0001066762,0.0001062744,1.18539e-7,0.00006097041,0.00146377,0.9912077,0.00004090444,0.0001590697,0.0006758239],"study_design_scores_gemma":[0.0006451515,0.0006175648,0.273798,0.00003449983,0.00007120585,0.000001548495,0.00001033997,0.00002679145,0.7244666,0.00007570432,0.000142808,0.0001098739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948241,0.0001950255,0.001528944,0.0000727593,0.00002538831,0.0008711213,0.002439301,0.000002807611,0.00004058912],"genre_scores_gemma":[0.9985193,0.0000225026,0.0008769652,0.00004733451,0.00001604141,0.00004700756,0.0004244417,0.00002119922,0.00002520797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.268167,"threshold_uncertainty_score":0.555693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0332405805067171,"score_gpt":0.2881966911520842,"score_spread":0.2549561106453671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}