{"id":"W2115276091","doi":"10.1016/j.bbamem.2015.03.010","title":"Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Chemistry; Lipid bilayer; Lipid raft; Context (archaeology); Nicotinic acetylcholine receptor; Biophysics; Torpedo; Transmembrane protein; Conformational change; Transmembrane domain; Acetylcholine receptor; Receptor; Biochemistry; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005394907,0.0008306298,0.00105146,0.0009769361,0.0002379384,0.000893879,0.000936509,0.001142979,0.001702464],"category_scores_gemma":[0.000588934,0.0002502383,0.0003051365,0.001381902,0.0005699157,0.001192192,0.0007709853,0.001352406,0.001406469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006807337,"about_ca_system_score_gemma":0.001081284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008966803,"about_ca_topic_score_gemma":0.001662763,"domain_scores_codex":[0.999904,0.00001235076,0.00001240596,0.00002341214,0.00003363579,0.00001416631],"domain_scores_gemma":[0.9998611,0.00005648977,0.00001864849,0.000005923536,0.00004212654,0.00001575608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001241634,0.00006586337,0.0002280394,0.01682295,0.00009729261,0.0003089565,0.00007124965,0.0005249456,0.008177808,0.008942059,0.03399631,0.9306403],"study_design_scores_gemma":[0.00001752508,0.00005850158,0.0005184386,0.001515728,0.0001106423,0.0007267268,0.00006183732,0.0001237011,0.001853682,0.003196667,0.9917964,0.0000202551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001472162,0.9983532,0.0002024826,0.0003185323,0.0001973057,0.0000032767,0.00002019019,0.000005344479,0.0007524589],"genre_scores_gemma":[0.0009398131,0.9980236,0.0001994347,0.0001645751,0.0001191258,0.000004465116,0.0000229947,8.3809e-7,0.000525113],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001702464,"threshold_uncertainty_score":0.005695283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05650995620183039,"score_gpt":0.3399419040702814,"score_spread":0.2834319478684509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}