{"id":"W2115276344","doi":"10.1126/science.1239947","title":"Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1387,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Temozolomide; Glioma; Exome sequencing; Medicine; Oncology; Mutation; Internal medicine; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061546,0.0001279255,0.0002178059,0.000579864,0.0001298291,0.000310109,0.0001009947,0.0002459152,0.0006582346],"category_scores_gemma":[0.0004448205,0.00008535512,0.0001695027,0.0003718628,0.0001095099,0.00009963687,0.0001279931,0.0001824612,0.0001779922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360444,"about_ca_system_score_gemma":0.00009194312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009287865,"about_ca_topic_score_gemma":0.001725861,"domain_scores_codex":[0.9999183,0.000009936532,0.000008131677,0.00001948561,0.00002285876,0.00002128068],"domain_scores_gemma":[0.9998475,0.00003137255,0.00005161416,0.00001813321,0.00002527523,0.00002600999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008778595,0.00006762279,0.1618008,0.00007583402,0.0001149594,0.002009542,0.000268954,0.0009075055,0.8073755,0.0002191043,0.0001847411,0.02609769],"study_design_scores_gemma":[0.00001967702,0.0005388303,0.8674803,0.00001310366,0.0001617314,0.008007176,0.0002562004,0.003305908,0.1176347,0.0001898598,0.00237711,0.00001542552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993734,0.0001199998,0.0001695703,0.00001350324,7.588125e-7,0.000003409939,0.0001231259,0.000007926706,0.0001883232],"genre_scores_gemma":[0.9992024,0.0001102406,0.0002257011,0.000012046,0.000001605765,0.000003233944,0.0002818499,0.000005479352,0.0001574474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009287865,"threshold_uncertainty_score":0.002202034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109787236291706,"score_gpt":0.2712316608139388,"score_spread":0.2602529371847682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}