{"id":"W2115278949","doi":"10.1111/j.1460-9568.2007.05557.x","title":"Insulin‐like growth factor‐1‐dependent maintenance of neuronal metabolism through the phosphatidylinositol 3‐kinase–Akt pathway is inhibited by C<sub>2</sub>‐ceramide in CAD cells","year":2007,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Ceramide; Protein kinase B; Biology; Phosphorylation; PI3K/AKT/mTOR pathway; Tyrosine phosphorylation; Cell biology; Lipid signaling; Phosphatidylinositol; Tyrosine hydroxylase; Endocrinology; Signal transduction; Internal medicine; Biochemistry; Apoptosis; Dopamine; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001726691,0.0003765349,0.000421259,0.0002444476,0.0003291077,0.0001570395,0.001448568,0.00005460584,0.000007212877],"category_scores_gemma":[0.0007936392,0.0002598982,0.0002248511,0.001321799,0.0007165308,0.001017479,0.000238785,0.0009471337,0.00001670446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006113881,"about_ca_system_score_gemma":0.0001346901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001235808,"about_ca_topic_score_gemma":0.000005034182,"domain_scores_codex":[0.9945121,0.001263764,0.001485164,0.0006734726,0.00137779,0.0006876634],"domain_scores_gemma":[0.9973594,0.0003999257,0.001337306,0.000432883,0.0002498535,0.0002206626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001596703,0.0002573318,0.00009336386,0.00001280534,0.000002028841,0.0005674103,0.0008170726,0.000284515,0.9946067,0.0004072611,0.000671885,0.002119941],"study_design_scores_gemma":[0.0009179796,0.0004146215,0.01509972,0.00006921451,0.00001181468,0.0002309015,0.00005434295,0.0001618042,0.9791073,0.00009287342,0.003587369,0.0002520536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914795,0.0003277526,0.003905612,0.000771675,0.002596698,0.0002841047,0.00008923138,0.00002396826,0.0005214812],"genre_scores_gemma":[0.9930547,0.0006202847,0.0001052796,0.005831152,0.0002024407,0.000001121403,7.164201e-7,0.00004805649,0.0001362095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01549941,"threshold_uncertainty_score":0.9999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02096401875499418,"score_gpt":0.2384679679506003,"score_spread":0.2175039491956061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}