{"id":"W2115300850","doi":"10.1016/j.jmb.2007.09.018","title":"Multiple Tryptophan Probes Reveal that Ubiquitin Folds via a Late Misfolded Intermediate","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ubiquitin; Tryptophan; Chemistry; Protein folding; Biophysics; Biochemistry; Cell biology; Computational biology; Biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408061,0.0004355398,0.0003097033,0.0002301459,0.0004253545,0.0005621942,0.0005096878,0.001019077,0.001949131],"category_scores_gemma":[0.0003309071,0.0002421735,0.0003478091,0.0001534921,0.000364786,0.0008503575,0.0004040859,0.001542676,0.0005260449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005421599,"about_ca_system_score_gemma":0.0001770818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002350359,"about_ca_topic_score_gemma":0.0003243301,"domain_scores_codex":[0.9998623,0.00002129235,0.000006163929,0.00004297557,0.00002525936,0.00004194339],"domain_scores_gemma":[0.999651,0.0001136889,0.00005453137,0.00006734252,0.00003987855,0.00007348516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000329145,0.00003746376,0.0003808341,0.00002080907,0.000009291893,0.0001874233,0.00002520081,0.0000949837,0.9966443,0.0006882072,0.00009678718,0.001485653],"study_design_scores_gemma":[0.00002224816,0.0001510791,0.001465753,0.000002739943,0.00001242558,0.0002689988,0.00003043534,0.00158833,0.995486,0.0003324678,0.0006332969,0.000006287687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800692,0.0005270573,0.01726383,0.0003101776,0.00003519816,0.00001830131,0.0001410659,0.0001393283,0.001495902],"genre_scores_gemma":[0.9908312,0.0001974338,0.005872092,0.0001621018,0.00001113521,0.00002052909,0.0002149201,0.00004928404,0.002641325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949131,"threshold_uncertainty_score":0.00652051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273344000644485,"score_gpt":0.2701448076330774,"score_spread":0.2574113676266325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}