{"id":"W2115310323","doi":"10.1074/jbc.m201731200","title":"Effects of N-Ethylmaleimide on Conformational Equilibria in Purified Cardiac Muscarinic Receptors","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Quinuclidinyl Benzilate; Muscarinic acetylcholine receptor; Chemistry; N-Ethylmaleimide; Carbachol; Dithiothreitol; Agonist; Receptor; Muscarinic acetylcholine receptor M2; Endocrinology; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004490125,0.0005930589,0.0003495322,0.0001174098,0.000170407,0.000293993,0.0004002931,0.0002241899,0.001837542],"category_scores_gemma":[0.0004380402,0.0002383568,0.0003228764,0.0001178952,0.0003098161,0.0002514051,0.0002776135,0.0007314141,0.0004941292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007107632,"about_ca_system_score_gemma":0.0003666572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399768,"about_ca_topic_score_gemma":0.002197912,"domain_scores_codex":[0.999743,0.00005430979,0.00002591127,0.0000563808,0.00006349445,0.00005692714],"domain_scores_gemma":[0.9997364,0.00008697413,0.00005775048,0.00003455668,0.00003407714,0.00005020828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002443506,0.00006133896,0.0001283278,0.00003973287,0.00001350993,0.00003208222,0.00002693254,0.00007472091,0.9984577,0.00007495473,0.0000232985,0.0008230718],"study_design_scores_gemma":[0.00002382833,0.0001985928,0.001749875,0.000004385023,0.00001047928,0.00005801209,0.00001072958,0.0007296892,0.9964406,0.00001362851,0.0007564775,0.000003738414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951755,0.0008996663,0.001565645,0.00007609483,0.00002813979,0.00004063886,0.0002044134,0.00007682187,0.001933184],"genre_scores_gemma":[0.9915338,0.001156176,0.002588922,0.00007394441,0.00001720978,0.00007040688,0.001062633,0.00006353833,0.003433331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837542,"threshold_uncertainty_score":0.006147206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595910680194462,"score_gpt":0.227912343017669,"score_spread":0.2119532362157244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}