{"id":"W2115338157","doi":"10.2337/db13-0863","title":"Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Proinflammatory cytokine; Islet; Amylin; CD11c; Endocrinology; Internal medicine; Genetically modified mouse; Tumor necrosis factor alpha; Amyloid (mycology); Inflammation; Biology; Chemistry; Cell biology; Transgene; Medicine; Diabetes mellitus; Phenotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662769,0.0002194333,0.000180872,0.0000615703,0.0001302474,0.00009757443,0.0001135608,0.0001454806,0.0001108446],"category_scores_gemma":[0.0001682827,0.0002049703,0.00007316329,0.0001081142,0.00006866497,0.00002188054,0.00009473391,0.0001106134,0.00010404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552058,"about_ca_system_score_gemma":0.00002444807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001221887,"about_ca_topic_score_gemma":0.00001591095,"domain_scores_codex":[0.9986628,0.00007112377,0.0002126933,0.0004790001,0.0001558961,0.000418538],"domain_scores_gemma":[0.9993709,0.00001565731,0.0001240991,0.0002777344,0.0001054977,0.0001061349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006077028,0.00005592818,0.01812503,0.00003318482,0.00005173246,3.158054e-7,0.00004967298,0.00000593904,0.9551238,0.000004716385,0.02305643,0.003487093],"study_design_scores_gemma":[0.0004640688,0.0002488977,0.02095131,0.00002168322,0.00003853503,4.303406e-7,0.0002589135,0.00003932824,0.9729034,0.0001951721,0.00456926,0.0003089504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957417,0.001568218,0.000003655598,0.0008909758,0.0004213927,0.0003169664,0.00002324898,0.00003919031,0.0009946899],"genre_scores_gemma":[0.9955871,0.0004561954,0.0000677046,0.0004928388,0.0003982373,0.00008777768,0.0001682353,0.00003713762,0.002704838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01848718,"threshold_uncertainty_score":0.8358445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004189077017435298,"score_gpt":0.1911037331710627,"score_spread":0.1869146561536274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}