{"id":"W2115338157","doi":"10.2337/db13-0863","title":"Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Proinflammatory cytokine; Islet; Amylin; CD11c; Endocrinology; Internal medicine; Genetically modified mouse; Tumor necrosis factor alpha; Amyloid (mycology); Inflammation; Biology; Chemistry; Cell biology; Transgene; Medicine; Diabetes mellitus; Phenotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686291,0.0008121696,0.0004828009,0.0002402094,0.0001501286,0.0003781064,0.0001678324,0.0003768042,0.0008102592],"category_scores_gemma":[0.0001732057,0.0001899629,0.0003316759,0.0001253149,0.0003255674,0.000298602,0.0004083652,0.0008577944,0.0004156833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752705,"about_ca_system_score_gemma":0.000150724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001143154,"about_ca_topic_score_gemma":0.0001231659,"domain_scores_codex":[0.999797,0.0000495746,0.00002064437,0.00004910209,0.00002815859,0.0000555953],"domain_scores_gemma":[0.9998544,0.00001641117,0.00005279847,0.00001693019,0.00001711748,0.00004227113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006001491,0.00009903659,0.001678242,0.00007830547,0.0000122046,0.0006635747,0.00008619273,0.0000340166,0.9945069,0.00008887341,0.00005550127,0.002097085],"study_design_scores_gemma":[0.0002431308,0.002965709,0.05004413,0.00006794827,0.0002058392,0.007470174,0.0004013684,0.00109407,0.9316278,0.0006762095,0.005178886,0.00002490877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929676,0.004216879,0.001962503,0.00009123711,0.0000377892,0.00003343124,0.00007030088,0.00005258554,0.000567688],"genre_scores_gemma":[0.9956225,0.002077157,0.001002497,0.0001138535,0.00005341775,0.00005856602,0.000117838,0.00001575282,0.0009384631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008121696,"threshold_uncertainty_score":0.002710581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004189077017435298,"score_gpt":0.1911037331710627,"score_spread":0.1869146561536274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}