{"id":"W2115343458","doi":"10.1126/scitranslmed.3003223","title":"Breast Cancer–Associated <i>Abraxas</i> Mutation Disrupts Nuclear Localization and DNA Damage Response Functions","year":2012,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"DNA damage; Breast cancer; Mutation; Cancer research; Germline mutation; Cancer; Germline; Genetics; Biology; DNA; Gene; DNA repair; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000884744,0.0001114567,0.0000898263,0.0001235293,0.0003858201,0.00001925263,0.0001138158,0.00005937641,0.0001531751],"category_scores_gemma":[0.0001657879,0.0001010637,0.00002017616,0.00057414,0.0007894813,0.00005503905,0.00002079453,0.00006422294,0.000006366235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007886462,"about_ca_system_score_gemma":0.0002621371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003768859,"about_ca_topic_score_gemma":0.00004393436,"domain_scores_codex":[0.9988157,0.00007670845,0.0001892266,0.000277525,0.0003923959,0.0002484977],"domain_scores_gemma":[0.9993566,0.0000407355,0.00007710882,0.0001497069,0.0002241407,0.0001517119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004824862,0.0001094997,0.0253404,0.00001683579,0.00004284314,0.000001023783,0.002688481,0.002421585,0.9583055,0.0007988982,0.002438108,0.007354323],"study_design_scores_gemma":[0.001823322,0.0002042094,0.9695891,0.00008191723,0.00009547999,0.0001187185,0.001028967,0.005248164,0.009314235,0.0002892316,0.01186047,0.0003462251],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854503,0.0005468937,0.006341332,0.006268206,0.000512571,0.0001835117,0.0001208462,0.00002581596,0.00055053],"genre_scores_gemma":[0.9985375,0.00004048129,0.0002142171,0.0005526321,0.00032816,0.00001983988,0.0001468287,0.00001530768,0.000145057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9489913,"threshold_uncertainty_score":0.4121258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190924029153127,"score_gpt":0.2910953933683194,"score_spread":0.2791861530767881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}