{"id":"W2115357159","doi":"10.1002/jcp.21321","title":"Activation of AMP‐activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin‐sensitizing effects of troglitazone in skeletal muscle cells","year":2007,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Troglitazone; Internal medicine; Endocrinology; Glucose uptake; Insulin; Pyruvate carboxylase; AMPK; Chemistry; Pyruvate dehydrogenase complex; Protein kinase B; Pyruvate kinase; AMP-activated protein kinase; Protein kinase A; Biochemistry; Metabolism; Biology; Glycolysis; Phosphorylation; Peroxisome proliferator-activated receptor; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623143,0.0008763958,0.0006965243,0.0002229489,0.0002399995,0.000297538,0.0002861125,0.0004377083,0.001237073],"category_scores_gemma":[0.0001161496,0.0002961575,0.0007136796,0.0001926528,0.0003873367,0.0003550935,0.0002499824,0.00119379,0.0003859429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002978746,"about_ca_system_score_gemma":0.0002761142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000631557,"about_ca_topic_score_gemma":0.001513998,"domain_scores_codex":[0.9998577,0.00002271885,0.00002044772,0.00003319024,0.00002482678,0.00004114316],"domain_scores_gemma":[0.9999121,0.00001558451,0.00003191117,0.00001437164,0.000009965395,0.00001598134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003358723,0.00003532039,0.0001250708,0.00006228847,0.000009163102,0.00004084137,0.00001239144,0.00004068614,0.9986799,0.00001504164,0.00001445647,0.0006289429],"study_design_scores_gemma":[0.00007577048,0.0009800358,0.006278784,0.0000114972,0.00003250975,0.0001410803,0.00003317436,0.0002725804,0.9913163,0.00002110978,0.0008320917,0.000005036326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877806,0.007392675,0.003206132,0.0001551565,0.00008359033,0.00005791254,0.0002497406,0.000107929,0.0009662627],"genre_scores_gemma":[0.9911998,0.004116543,0.002436894,0.0001183972,0.00003121031,0.000108488,0.0004739797,0.00001844774,0.001496299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237073,"threshold_uncertainty_score":0.00413841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005473601499468083,"score_gpt":0.2209982629962844,"score_spread":0.2155246614968163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}