{"id":"W2115380566","doi":"10.1002/cmdc.200600173","title":"Steroid Conjugates of Dichloro(6‐aminomethylnicotinate)platinum(II): Effects on DNA, Sex Hormone Binding Globulin, the Estrogen Receptor, and Various Breast Cancer Cell Lines","year":2007,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"Deutsche Forschungsgemeinschaft","keywords":"Sex hormone-binding globulin; Conjugate; Estrogen; Estrogen receptor; Chemistry; Internal medicine; Endocrinology; In vitro; Steroid; Receptor; Steroid hormone; Hormone; Biology; Biochemistry; Breast cancer; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007115494,0.0003155504,0.000596361,0.00006344412,0.0001768998,0.00002532327,0.0001792023,0.0001434385,0.0001321325],"category_scores_gemma":[0.0001232955,0.0001950146,0.00012255,0.0001810993,0.0002081025,0.00006726673,0.0001413192,0.0002423472,0.0000169681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008382789,"about_ca_system_score_gemma":0.00004464611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001832347,"about_ca_topic_score_gemma":0.0000145196,"domain_scores_codex":[0.9983547,0.00005390776,0.0004649514,0.0003646899,0.0003483479,0.0004133519],"domain_scores_gemma":[0.9985014,0.000589939,0.0002426084,0.0003791534,0.0001095087,0.0001773512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005360437,0.0001503455,0.004966307,0.0003835451,0.0001248256,0.000005047948,0.0008771534,4.938836e-7,0.9696007,0.00002846927,0.0005737351,0.0227533],"study_design_scores_gemma":[0.001195157,0.0004875983,0.01155962,0.0002313494,0.0001476545,0.00002867502,0.0003749277,0.00003312128,0.9844882,0.00002492158,0.001221454,0.0002073574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837378,0.01205428,0.00001104278,0.0006795944,0.0001426013,0.0004632986,0.00003603612,0.00004689419,0.002828453],"genre_scores_gemma":[0.9966568,0.0006967661,0.000352913,0.0003365218,0.0003444544,0.00002839853,0.00002135747,0.00004582806,0.001516966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02254594,"threshold_uncertainty_score":0.7952465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806205240935415,"score_gpt":0.2503797459859354,"score_spread":0.2323176935765812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}