{"id":"W2115436861","doi":"10.1002/pros.23052","title":"DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence","year":2015,"lang":"en","type":"article","venue":"The Prostate","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Mitacs; CancerCare Manitoba Foundation","keywords":"DNA methylation; Methylation; CpG site; Biology; Epigenetics; Prostate cancer; Differentially methylated regions; breakpoint cluster region; Cancer research; Cancer; Oncology; Genetics; Internal medicine; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001268067,0.0001240222,0.0001785607,0.00004307279,0.00007655639,0.00003357122,0.0001103978,0.00006570847,7.278374e-7],"category_scores_gemma":[0.0004240893,0.00009677442,0.00005345424,0.00009678087,0.0001897996,0.00001478205,0.0001107882,0.00007035373,2.730318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001008133,"about_ca_system_score_gemma":0.0001122165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125305,"about_ca_topic_score_gemma":0.000008438033,"domain_scores_codex":[0.9989629,0.0001370446,0.000330703,0.0002389862,0.0001620358,0.0001683401],"domain_scores_gemma":[0.9989873,0.00007208606,0.00039476,0.0002255642,0.0002571584,0.00006316233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004864164,0.00002080945,0.01151569,0.000113604,0.00005907104,2.741551e-7,0.0005838472,0.0001996305,0.9730994,0.00001626256,0.0001001464,0.01380484],"study_design_scores_gemma":[0.0006707693,0.0002495305,0.01410413,0.00007115739,0.00006573382,0.00000173944,0.0003288375,0.0005502346,0.9807299,0.002690263,0.0004048845,0.0001327748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905158,0.002752761,0.00578898,0.0000851392,0.00006281447,0.0004916509,0.0001012027,0.000005684417,0.0001959296],"genre_scores_gemma":[0.9954861,0.0006101254,0.003490057,0.00001309812,0.00003416179,0.0000278364,0.0001956791,0.00001744231,0.000125454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01367207,"threshold_uncertainty_score":0.3946346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020699656308104,"score_gpt":0.2885944416612428,"score_spread":0.2683874450981618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}