{"id":"W2115453935","doi":"10.4049/jimmunol.1500564","title":"Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Sanofi; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Norges Forskningsråd; Agence Nationale de la Recherche; National Science Foundation","keywords":"Adjuvant; CD8; Dendritic cell; Immunology; Cross-presentation; Dermis; Immune system; Immunotherapy; Melanoma; Cancer research; Medicine; Pathology; MHC class I","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389381,0.0002594218,0.0002326988,0.0001805852,0.00009214772,0.0002011921,0.0001075246,0.000305897,0.0007403482],"category_scores_gemma":[0.00007908011,0.0000877654,0.0001667885,0.000132631,0.0001386886,0.0001518967,0.0001211702,0.0005330513,0.0003008411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103008,"about_ca_system_score_gemma":0.0002199605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002374045,"about_ca_topic_score_gemma":0.0003544848,"domain_scores_codex":[0.9998531,0.00001534023,0.00001158427,0.00003981972,0.00003508769,0.00004507529],"domain_scores_gemma":[0.9999398,0.00001129235,0.00001918857,0.000009935038,0.000007638861,0.00001209128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000683106,0.00004476267,0.00005441788,0.00003230216,0.000001835598,0.00001367539,0.000006021463,0.00009623349,0.9981434,0.00004487945,0.00003513157,0.001459098],"study_design_scores_gemma":[0.00001884956,0.0005476605,0.0006763181,0.000003767856,0.00000833416,0.00008546022,0.000007822637,0.0009000654,0.996524,0.00002083638,0.001204528,0.000002273757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896571,0.00186478,0.006194024,0.0001091228,0.00005086123,0.0001016484,0.0003707216,0.0001509998,0.001500698],"genre_scores_gemma":[0.9900169,0.001231071,0.005720702,0.00007949145,0.00002752325,0.00008072471,0.0004270787,0.00002417511,0.002392473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007403482,"threshold_uncertainty_score":0.002476692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367596387133321,"score_gpt":0.2447431993971761,"score_spread":0.2210672355258429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}