{"id":"W2115453935","doi":"10.4049/jimmunol.1500564","title":"Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Sanofi; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Norges Forskningsråd; Agence Nationale de la Recherche; National Science Foundation","keywords":"Adjuvant; CD8; Dendritic cell; Immunology; Cross-presentation; Dermis; Immune system; Immunotherapy; Melanoma; Cancer research; Medicine; Pathology; MHC class I","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00205225,0.0003221823,0.0008580387,0.0004343229,0.0002482189,0.00001924082,0.001429135,0.0003422149,0.0001634221],"category_scores_gemma":[0.0007986565,0.0002164407,0.0002628197,0.0002833681,0.0007165986,0.0003168743,0.0003112783,0.0009283529,0.0000705212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007955877,"about_ca_system_score_gemma":0.000510421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798129,"about_ca_topic_score_gemma":0.000007434401,"domain_scores_codex":[0.995246,0.002598932,0.001294888,0.0001638554,0.0001279214,0.0005684123],"domain_scores_gemma":[0.9964355,0.001115254,0.001172915,0.0005997673,0.0006403466,0.00003619076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01046127,0.0003204298,0.0003119214,0.00001477891,0.0009438673,0.00006446912,0.00162049,0.00002689605,0.9746919,0.00004398423,0.004826765,0.006673271],"study_design_scores_gemma":[0.005511462,0.002442959,0.01502384,0.0001498048,0.0002537646,0.004323823,0.005759112,0.000002935346,0.9594573,0.0001683759,0.006646304,0.0002602881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195979,0.07630991,0.00006517443,0.001272382,0.002480399,0.0001528374,0.00002352989,0.00002613904,0.00007178309],"genre_scores_gemma":[0.9957207,0.003007264,0.0002212085,0.0001744972,0.00008494638,0.000002629545,0.000009120432,0.00003323178,0.0007464068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07612285,"threshold_uncertainty_score":0.8826194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367596387133321,"score_gpt":0.2447431993971761,"score_spread":0.2210672355258429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}