{"id":"W2115485185","doi":"10.1002/prot.21850","title":"Binding of sulfonium‐ion analogues of di‐<i>epi</i>‐swainsonine and 8‐<i>epi</i>‐lentiginosine to <i>Drosophila</i> Golgi α‐mannosidase II: The role of water in inhibitor binding","year":2007,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Simon Fraser University","funders":"National Center for Research Resources","keywords":"Sulfonium; Swainsonine; Chemistry; Stereochemistry; Molecule; Hydrolase; Binding site; Mannosidase; Steric effects; Active site; Golgi apparatus; Anomer; Glycoside hydrolase; Enzyme; Salt (chemistry); Endoplasmic reticulum; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009129477,0.0003281238,0.0003132277,0.00006292453,0.00006793765,0.0001671621,0.000354851,0.0002506856,0.0009341402],"category_scores_gemma":[0.0001562934,0.0001163879,0.0001812998,0.00009345858,0.0001615118,0.0001255702,0.0001247305,0.0002563616,0.0001915224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003311804,"about_ca_system_score_gemma":0.0002364573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001876412,"about_ca_topic_score_gemma":0.002231975,"domain_scores_codex":[0.9999331,0.00001068249,0.000005512659,0.00001451417,0.00001718175,0.00001896748],"domain_scores_gemma":[0.9999447,0.00001017614,0.00001695266,0.000003318292,0.000007537701,0.00001734998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006621275,0.00006327073,0.0003218781,0.00008638489,0.00002558552,0.00006698615,0.00002703349,0.001032789,0.9950459,0.0001014244,0.0000554342,0.002511188],"study_design_scores_gemma":[0.00009207254,0.00155529,0.001411638,0.000004680973,0.00002861317,0.0001136843,0.00002749194,0.002484758,0.9931322,0.00002504244,0.0011146,0.000009904887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973997,0.0007132067,0.0006730299,0.0000204766,0.000009770652,0.00002490929,0.0001097803,0.00002323093,0.001025867],"genre_scores_gemma":[0.9975094,0.000507134,0.000982634,0.00002227355,0.000002829252,0.00001472814,0.0002628598,0.000006283743,0.0006918192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876412,"threshold_uncertainty_score":0.003731012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005669089853732719,"score_gpt":0.1928009934718853,"score_spread":0.1871319036181526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}