{"id":"W2115519453","doi":"10.1128/jb.00085-11","title":"Age of Inoculum Strongly Influences Persister Frequency and Can Mask Effects of Mutations Implicated in Altered Persistence","year":2011,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Institute of Genetics; Eesti Teadusfondi; Keio University","keywords":"Multidrug tolerance; Biology; Microbiology; Bacteria; Escherichia coli; Stationary phase; Mutant; Antibiotics; Mutation frequency; Persistence (discontinuity); Amikacin; Virulence; Genetics; Gene; Biofilm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004673991,0.0004171651,0.0006008114,0.0003422236,0.000157758,0.0005318912,0.0003227062,0.0005107711,0.002263893],"category_scores_gemma":[0.001190383,0.0002907341,0.0002918997,0.0001723026,0.0002397198,0.0004256721,0.0005745362,0.0009028371,0.0004315624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924116,"about_ca_system_score_gemma":0.000201906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005794778,"about_ca_topic_score_gemma":0.0006032079,"domain_scores_codex":[0.9992626,0.0001276266,0.00009155556,0.000189156,0.0001893981,0.000139625],"domain_scores_gemma":[0.9985223,0.0005741152,0.0003409828,0.0001995749,0.0001580537,0.0002048608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101359,0.00003119413,0.001069335,0.00002422384,0.000003779516,0.00002944199,0.00001569109,0.00002951928,0.9979723,0.00001477962,0.00001182157,0.0006876137],"study_design_scores_gemma":[0.00001101443,0.001124658,0.04557713,0.00002199301,0.00005006085,0.0002855905,0.00006917053,0.001308402,0.9500707,0.00007720741,0.001380851,0.00002333765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938339,0.001379911,0.003026172,0.00009473582,0.00007134401,0.00006099915,0.0005720406,0.00007387067,0.0008870916],"genre_scores_gemma":[0.9942191,0.0007485312,0.002396682,0.0001070362,0.00002547171,0.00009220556,0.0007900088,0.00008877138,0.001532205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002263893,"threshold_uncertainty_score":0.007573485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567926536357325,"score_gpt":0.228865935085688,"score_spread":0.2131866697221147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}