{"id":"W2115528152","doi":"10.1016/s1470-2045(15)00038-8","title":"Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Astex Pharmaceuticals; National Cancer Institute; Stand Up To Cancer; Entertainment Industry Foundation","keywords":"Tolerability; Medicine; Decitabine; International Prognostic Scoring System; Internal medicine; Hypomethylating agent; Myelodysplastic syndromes; Adverse effect; Neutropenia; Febrile neutropenia; Oncology; Pharmacology; Gastroenterology; Bone marrow; Toxicity; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001916194,0.0002195982,0.001228801,0.0001446612,0.00006152816,0.00001118622,0.0001602182,0.0001490428,0.00002597286],"category_scores_gemma":[0.0007440055,0.0001330769,0.00002794166,0.0003398359,0.0004002276,0.0001250972,0.0001834646,0.0005503343,0.000005452789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005741566,"about_ca_system_score_gemma":0.000389011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001359085,"about_ca_topic_score_gemma":0.0002121109,"domain_scores_codex":[0.9975485,0.0006267449,0.0005852141,0.0004000824,0.0004154185,0.0004241035],"domain_scores_gemma":[0.9979631,0.0008822665,0.0002121509,0.0004671736,0.0002527052,0.0002225498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2177238,0.002762782,0.7624103,0.0001305609,0.0003862571,0.0002236634,0.00503087,0.00006036277,0.0002266317,0.00002209169,0.0001650611,0.01085771],"study_design_scores_gemma":[0.2731938,0.007269889,0.7163388,0.00004892046,0.0002860221,0.0001089454,0.0007846119,0.001610299,0.00001878568,0.00003415666,0.000193062,0.0001127838],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947577,0.0001065094,0.00007928524,0.001382506,0.0000638538,0.003181394,0.00003358941,0.00002681448,0.0003683778],"genre_scores_gemma":[0.9989232,0.00007719749,0.0005791194,0.0001521912,0.00006523077,0.0000754147,0.00004072548,0.00002191974,0.00006493303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05547002,"threshold_uncertainty_score":0.5426717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983554464073441,"score_gpt":0.3333968728278118,"score_spread":0.3035613281870774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}