{"id":"W2115543229","doi":"10.1093/hmg/11.20.2517","title":"Pharmacogenomics in schizophrenia: the quest for individualized therapy","year":2002,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Pharmacogenomics; Pharmacogenetics; Biology; Candidate gene; Schizophrenia (object-oriented programming); Clozapine; Neurocognitive; Bioinformatics; Genetics; Gene; Neuroscience; Psychiatry; Genotype; Medicine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003349942,0.0005778352,0.001398488,0.000340051,0.0001553366,0.00008415253,0.0004756089,0.0003092684,0.000138403],"category_scores_gemma":[0.00003988906,0.0003754307,0.0008107386,0.0003358305,0.0001351081,0.00001216384,0.0001091388,0.0006201645,0.00007173201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139363,"about_ca_system_score_gemma":0.0004629297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009037564,"about_ca_topic_score_gemma":0.0000235776,"domain_scores_codex":[0.9974223,0.0002818252,0.0006714053,0.000594635,0.0004433612,0.0005864481],"domain_scores_gemma":[0.998471,0.0001417343,0.0002111598,0.0008704428,0.00008734457,0.0002182674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003359493,0.0003438394,0.000006896364,0.001630082,0.0008869474,0.0002771176,0.00005066486,0.000001510224,0.00004207118,0.0006648968,0.0004965949,0.9952635],"study_design_scores_gemma":[0.009338419,0.0005066933,0.00007130742,0.001557072,0.001240185,0.0001210332,0.000004655195,0.00002023648,0.00009639058,0.0006150181,0.9860469,0.0003820633],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00181856,0.9924369,0.00004096047,0.00008940215,0.00009098068,0.005073099,0.0001116865,0.00003623445,0.0003021784],"genre_scores_gemma":[0.0002487797,0.9938816,0.003188329,0.000173781,0.0002989818,0.001287945,0.0005490636,0.0001787404,0.0001927976],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9948814,"threshold_uncertainty_score":0.9998698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262608731518765,"score_gpt":0.4158637969052974,"score_spread":0.2896029237534209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}