{"id":"W2115551787","doi":"10.1021/ol049853c","title":"Synthesis of a New Chiral Nonracemic <i>C</i><sub>2</sub>-Symmetric 2,2‘-Bipyridyl Ligand and Its Application in Copper(I)-Catalyzed Enantioselective Cyclopropanation Reactions","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cyclopropanation; Chemistry; Enantioselective synthesis; Copper; Catalysis; Ligand (biochemistry); Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219636,0.0003705354,0.0002623904,0.0001834803,0.0002130281,0.0003298491,0.0004600236,0.0002969353,0.001991735],"category_scores_gemma":[0.0001361169,0.0001487494,0.0001216556,0.0001692511,0.0002355496,0.0002726268,0.0002271118,0.0004043358,0.0009298765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004969432,"about_ca_system_score_gemma":0.0003794045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006099644,"about_ca_topic_score_gemma":0.0007748337,"domain_scores_codex":[0.9999083,0.0000131555,0.000006712858,0.00002267879,0.00002238836,0.00002678227],"domain_scores_gemma":[0.9999233,0.00000847934,0.00002210339,0.000006161214,0.00001124745,0.00002880394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007966535,0.00002986801,0.00007769066,0.0001521343,0.000004235656,0.0002479502,0.0000381309,0.0004814898,0.9897227,0.001282715,0.0003356078,0.007547774],"study_design_scores_gemma":[0.000030655,0.0001397039,0.0002639109,0.000007350447,0.000006483061,0.000479554,0.00001509529,0.0009900852,0.9907976,0.0001351236,0.007121316,0.00001304215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9345936,0.004593301,0.04255196,0.0007408915,0.0001737098,0.0001129656,0.0008366946,0.0006502601,0.01574683],"genre_scores_gemma":[0.9709046,0.001620247,0.01938209,0.000183714,0.00003490502,0.00006607085,0.0006353844,0.00008110137,0.007091741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991735,"threshold_uncertainty_score":0.006663084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006270974235281249,"score_gpt":0.2044813684643357,"score_spread":0.1982103942290545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}