{"id":"W2115602300","doi":"10.1158/0008-5472.can-14-0130","title":"Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"University of Pennsylvania","keywords":"Medicine; Pharmacology; Mevalonate pathway; Statin; In vivo; HMG-CoA reductase; Cancer research; Reductase; Internal medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005148295,0.0005855366,0.0006502786,0.0005147335,0.0002213514,0.0005552359,0.0002834161,0.0005727248,0.002058715],"category_scores_gemma":[0.0002471546,0.0001370681,0.0004467904,0.0001899967,0.0002645265,0.0003660005,0.0003999237,0.000892884,0.000347519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004077744,"about_ca_system_score_gemma":0.000606067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002311419,"about_ca_topic_score_gemma":0.0008586367,"domain_scores_codex":[0.999679,0.00007191385,0.00003180566,0.00006491871,0.00009339899,0.00005897987],"domain_scores_gemma":[0.9997924,0.00003555023,0.00005301255,0.00002703828,0.00004264897,0.00004932654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002691361,0.001293048,0.003010036,0.0004224868,0.0001008767,0.0003746405,0.00003551867,0.0001670488,0.87769,0.001066917,0.000610492,0.1125376],"study_design_scores_gemma":[0.001041158,0.02744213,0.01745893,0.00008560196,0.000505055,0.00282514,0.0001071643,0.0008365604,0.895852,0.0005693253,0.05324542,0.00003166892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8871539,0.08058603,0.01559584,0.003413726,0.0007354244,0.0005155526,0.000662941,0.0003240521,0.01101253],"genre_scores_gemma":[0.9667947,0.01698812,0.01040689,0.0008762574,0.0002533766,0.0001478218,0.0006323063,0.00002367411,0.00387694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058715,"threshold_uncertainty_score":0.006887078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05624920454799268,"score_gpt":0.3701558982658539,"score_spread":0.3139066937178612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}