{"id":"W2115606055","doi":"10.1242/dev.01265","title":"The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system","year":2004,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Haploinsufficiency; Electrical conduction system of the heart; Biology; Bundle; Anatomy; Bundle branches; Transcription factor; Internal medicine; Atrioventricular node; Cardiology; Cell biology; Electrocardiography; Materials science; Phenotype; Medicine; Gene; Genetics; Tachycardia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109849,0.0002485413,0.0001272169,0.0003052101,0.0001509905,0.0002679285,0.0001937546,0.000297936,0.001134756],"category_scores_gemma":[0.0001496048,0.0001961753,0.0001763055,0.00007163653,0.0002246099,0.0001770405,0.0002404947,0.0003203016,0.0003463162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310978,"about_ca_system_score_gemma":0.0001224636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006187037,"about_ca_topic_score_gemma":0.0007905941,"domain_scores_codex":[0.9998406,0.00002873313,0.00002297815,0.00003750775,0.00003989904,0.00003017813],"domain_scores_gemma":[0.9997583,0.00003375904,0.0001009065,0.0000220747,0.00001489967,0.0000699649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005529245,0.000004697756,0.0003873109,0.00001396745,0.000002819147,0.0001042296,0.00001258435,0.00007575738,0.9986063,0.00009982357,0.00001026174,0.000627124],"study_design_scores_gemma":[0.00003318603,0.0003130485,0.01304694,0.000019249,0.00002591352,0.0008559393,0.00003770971,0.002010344,0.9810246,0.0001282351,0.002498301,0.000006425949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959574,0.0009000011,0.002293831,0.00003189817,0.000007490423,0.000007967692,0.0001475395,0.00005457062,0.0005992519],"genre_scores_gemma":[0.9967943,0.000291675,0.00150691,0.00001694617,0.000003966764,0.0000109255,0.0001980922,0.00002570935,0.001151426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134756,"threshold_uncertainty_score":0.003796101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169100708432777,"score_gpt":0.2627747765746853,"score_spread":0.2410837694903575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}