{"id":"W2115640450","doi":"10.1523/jneurosci.20-24-09126.2000","title":"Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Deutsche Forschungsgemeinschaft","keywords":"MPTP; Pars compacta; Substantia nigra; XIAP; Glial cell line-derived neurotrophic factor; Neurotrophic factors; Dopaminergic; Programmed cell death; Inhibitor of apoptosis; Chemistry; Biology; Cell biology; Dopamine; Neuroscience; Caspase; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486675,0.000160987,0.0002765305,0.000104896,0.00003609,0.00001283001,0.0003305831,0.00008222731,0.000003211423],"category_scores_gemma":[0.0002043562,0.000118211,0.0001227617,0.0002370368,0.0002678858,0.00002442379,0.00002557149,0.0001874688,2.069703e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006466652,"about_ca_system_score_gemma":0.000106235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009815831,"about_ca_topic_score_gemma":8.27641e-7,"domain_scores_codex":[0.9985926,0.0001630518,0.0005162802,0.0002421048,0.0003126469,0.000173273],"domain_scores_gemma":[0.9993143,0.00004533183,0.0002411048,0.0001941009,0.0001168128,0.00008832978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005627734,0.0003034418,0.0001813802,0.0001010151,0.000005735108,0.000007300707,0.00008452881,0.002722434,0.9956146,1.853336e-7,0.00001257361,0.0004039564],"study_design_scores_gemma":[0.0008589676,0.001933368,0.004077304,0.00006260422,0.00003671906,0.000005718262,0.000006942807,0.004997521,0.9878875,0.000005237677,0.00002872387,0.00009940293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978508,0.0004737601,0.001131375,0.00006079039,0.0001393873,0.0002606179,0.00007910051,0.00000176969,0.000002351863],"genre_scores_gemma":[0.9982911,0.001493367,0.00003574148,0.00008761144,0.0000533256,0.000007400447,0.000003109567,0.00001211043,0.00001622439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007727185,"threshold_uncertainty_score":0.4820505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381696465714751,"score_gpt":0.2217565577702916,"score_spread":0.2079395931131441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}