{"id":"W2115640450","doi":"10.1523/jneurosci.20-24-09126.2000","title":"Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Deutsche Forschungsgemeinschaft","keywords":"MPTP; Pars compacta; Substantia nigra; XIAP; Glial cell line-derived neurotrophic factor; Neurotrophic factors; Dopaminergic; Programmed cell death; Inhibitor of apoptosis; Chemistry; Biology; Cell biology; Dopamine; Neuroscience; Caspase; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810526,0.0004860441,0.0003935613,0.0002386493,0.0001022895,0.0002779218,0.0002378289,0.0003083425,0.0006872758],"category_scores_gemma":[0.0001487725,0.0001598196,0.0003529278,0.0001355808,0.0002345261,0.0002597024,0.0002243381,0.0005727245,0.0001531899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138317,"about_ca_system_score_gemma":0.0002620294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003392292,"about_ca_topic_score_gemma":0.000484134,"domain_scores_codex":[0.9998298,0.00003463943,0.00002168507,0.00003319653,0.0000356212,0.00004506456],"domain_scores_gemma":[0.9998975,0.00001926098,0.00002958437,0.00001458447,0.000009507837,0.00002958601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009063925,0.0001840494,0.0002954885,0.00009982543,0.00003649699,0.0001222683,0.00002901104,0.0002108582,0.9944755,0.0002182069,0.00005342547,0.0033684],"study_design_scores_gemma":[0.0002243102,0.003843246,0.003722843,0.00001610472,0.0001342305,0.0007545601,0.00004172914,0.001842465,0.9870063,0.0001116901,0.002293248,0.000009297481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995548,0.002104838,0.001195232,0.00005331915,0.00003720459,0.00003120149,0.00008908897,0.00004508046,0.000896011],"genre_scores_gemma":[0.9963312,0.001037615,0.001417513,0.00002383003,0.00001426817,0.00004077159,0.0001587487,0.000006840675,0.0009693383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006872758,"threshold_uncertainty_score":0.00229913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381696465714751,"score_gpt":0.2217565577702916,"score_spread":0.2079395931131441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}