{"id":"W2115670666","doi":"10.1038/ja.2006.26","title":"3-Normeridamycin: A Potent Non-Immunosuppressive Immunophilin Ligand is Neuroprotective in Dopaminergic Neurons","year":2006,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Neurotoxin; Neuroprotection; Dopaminergic; Chemistry; Streptomyces; Dopamine; Pharmacology; Parkinsonism; EC50; Stereochemistry; Biology; Biochemistry; In vitro; Medicine; Internal medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003431482,0.0001824572,0.0002090479,0.0000725912,0.00008069261,0.00002808372,0.000446967,0.0000930746,0.000004692144],"category_scores_gemma":[0.0001118255,0.0001310274,0.0001500363,0.0001669655,0.0001483995,0.000007167165,0.0001269685,0.0003166281,0.000004695775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001936604,"about_ca_system_score_gemma":0.0001210012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005139069,"about_ca_topic_score_gemma":0.000006547535,"domain_scores_codex":[0.9987798,0.0001376156,0.0004661255,0.0001479322,0.0002230959,0.0002454618],"domain_scores_gemma":[0.9989678,0.00003896112,0.0003849495,0.0003753077,0.0001827783,0.00005021344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000404521,0.0001861412,0.002486065,0.0000124943,0.00004362916,0.00009522289,0.0001103682,0.003406906,0.9921244,0.000004445244,0.000965683,0.0001600612],"study_design_scores_gemma":[0.0009287047,0.0006549041,0.027004,0.00007209436,0.00006810886,0.000240016,0.0001199155,0.000212827,0.9699895,0.0001416531,0.0004148334,0.0001533882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997084,0.001348662,0.000444482,0.000406513,0.0002805952,0.0001604869,0.00001805676,0.000003202396,0.0002539815],"genre_scores_gemma":[0.9987384,0.0003114755,0.0001515466,0.0002806609,0.0003425828,6.290908e-8,0.000004539206,0.00002955903,0.0001411632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02451794,"threshold_uncertainty_score":0.5343144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004616158213886698,"score_gpt":0.2155581086484901,"score_spread":0.2109419504346034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}