{"id":"W2115675218","doi":"10.1155/2013/242513","title":"PKM2, a Central Point of Regulation in Cancer Metabolism","year":2013,"lang":"en","type":"article","venue":"International Journal of Cell Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Kidney Foundation of Canada","keywords":"PKM2; Glycolysis; Anaerobic glycolysis; Pyruvate kinase; Carcinogenesis; Biochemistry; Warburg effect; Oxidative phosphorylation; Kinase; Cell biology; Biology; Chemistry; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469322,0.00008855897,0.0001949445,0.0001411543,0.000007610834,0.000008509424,0.0002602388,0.0001119225,0.0002695768],"category_scores_gemma":[0.00005036353,0.00007454828,0.0001241825,0.00004814888,0.00006330517,0.00001262069,0.00005070985,0.00009532959,0.000003092546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002494123,"about_ca_system_score_gemma":0.0001316656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003055914,"about_ca_topic_score_gemma":0.00007239492,"domain_scores_codex":[0.9991144,0.00006237325,0.0004339613,0.0001164745,0.0001211435,0.0001516651],"domain_scores_gemma":[0.9990523,0.00001303401,0.0003710234,0.00008761205,0.0004214704,0.00005457379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306757,0.0000772215,0.003259612,0.000003926837,0.00006146255,7.101555e-7,0.00007652392,0.000243033,0.9829538,0.000226162,0.001527169,0.01143965],"study_design_scores_gemma":[0.001930061,0.0001436633,0.09559032,0.00002495735,0.00002553933,0.00003754316,0.00006373841,0.0000821252,0.7385198,0.001489192,0.1619594,0.0001336654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896147,0.00474151,0.0008177065,0.0005047899,0.003398467,0.00008324788,0.00001942934,0.000001314971,0.0008188725],"genre_scores_gemma":[0.994297,0.002718954,0.0006164475,0.0002242383,0.001874161,0.000006315445,0.00002169885,0.000007996693,0.0002332282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2444341,"threshold_uncertainty_score":0.3039991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007366494485480539,"score_gpt":0.2632758784405547,"score_spread":0.2559093839550742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}