{"id":"W2115675218","doi":"10.1155/2013/242513","title":"PKM2, a Central Point of Regulation in Cancer Metabolism","year":2013,"lang":"en","type":"article","venue":"International Journal of Cell Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Kidney Foundation of Canada","keywords":"PKM2; Glycolysis; Anaerobic glycolysis; Pyruvate kinase; Carcinogenesis; Biochemistry; Warburg effect; Oxidative phosphorylation; Kinase; Cell biology; Biology; Chemistry; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273628,0.0003553515,0.0003660472,0.0003172368,0.0005235036,0.001126195,0.0003545954,0.0005981341,0.001046876],"category_scores_gemma":[0.0002147006,0.0001385954,0.0002112697,0.0003639142,0.0005302022,0.0006752049,0.0005788865,0.0007648355,0.000593945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000629643,"about_ca_system_score_gemma":0.0003476519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003344612,"about_ca_topic_score_gemma":0.0002268744,"domain_scores_codex":[0.9997903,0.00002943498,0.0000105471,0.00007405178,0.0000576872,0.00003804776],"domain_scores_gemma":[0.9998838,0.00001303074,0.00003061206,0.000009869362,0.00002961683,0.00003309048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004725324,0.00006106675,0.004402122,0.0005234374,0.00002806076,0.001102138,0.0002804162,0.000907196,0.901894,0.02014917,0.004103685,0.06607613],"study_design_scores_gemma":[0.00005583122,0.0004739439,0.04025197,0.000136085,0.0000548925,0.00480305,0.0004934176,0.005720798,0.6823859,0.01524584,0.2502958,0.00008249957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5871316,0.2730971,0.08252622,0.00847804,0.002032004,0.0002008963,0.00147771,0.001558492,0.04349797],"genre_scores_gemma":[0.9444537,0.03310215,0.008336403,0.0005429168,0.000482091,0.00006967238,0.0005225177,0.00005669399,0.0124338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126195,"threshold_uncertainty_score":0.004568458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007366494485480539,"score_gpt":0.2632758784405547,"score_spread":0.2559093839550742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}