{"id":"W2115698961","doi":"10.1016/j.schres.2010.09.025","title":"PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: Implications for the treatment of negative symptoms in schizophrenia","year":2010,"lang":"en","type":"article","venue":"Schizophrenia Research","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"NMDA receptor; Antagonist; Dizocilpine; Allosteric regulation; Pharmacology; Allosteric modulator; Chemistry; Phencyclidine; Glutamate receptor; Receptor; Dopamine; Dopamine antagonist; Schizophrenia (object-oriented programming); Receptor antagonist; Internal medicine; Endocrinology; Psychology; Neuroscience; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115326,0.0004187071,0.0003527085,0.0002358525,0.0001851205,0.0002503848,0.0003775488,0.000333343,0.001499192],"category_scores_gemma":[0.0002094966,0.0001918541,0.0001681037,0.000157927,0.0004934469,0.0003355571,0.0001666895,0.001041867,0.0004071271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002026453,"about_ca_system_score_gemma":0.0005193828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009088845,"about_ca_topic_score_gemma":0.001864381,"domain_scores_codex":[0.9999527,0.000008603748,0.000003265147,0.000006891603,0.000009429312,0.00001924583],"domain_scores_gemma":[0.9999062,0.00001712439,0.00002415701,0.000008359401,0.000005605122,0.00003852118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00331897,0.0004648552,0.0004445746,0.0001713968,0.00002480842,0.0003506804,0.00004209984,0.0002155336,0.9820496,0.0007492444,0.0004581819,0.01171007],"study_design_scores_gemma":[0.002361221,0.01524234,0.01279422,0.00002713823,0.0001045286,0.002036175,0.0001118114,0.001236878,0.9575443,0.0005348541,0.007968949,0.00003756181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932243,0.0013987,0.001213019,0.0002587785,0.00004072088,0.00008618991,0.0003293813,0.0001155932,0.00333338],"genre_scores_gemma":[0.9932161,0.002689558,0.001626736,0.0001498782,0.00003383207,0.00007626719,0.0005154321,0.00001894729,0.001673157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499192,"threshold_uncertainty_score":0.005015314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07748517863301425,"score_gpt":0.3998397245011528,"score_spread":0.3223545458681386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}