{"id":"W2115714615","doi":"10.1002/jps.21855","title":"Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology**All authors are current or former employees of Wyeth, Inc.","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Biodistribution; In vivo; Pharmacology; Monoclonal antibody; Pharmacokinetics; Drug; Medicine; Chemistry; Cancer research; Computational biology; Antibody; In vitro; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005599841,0.000294085,0.0001915531,0.0002929874,0.0002445308,0.0006684089,0.0003200904,0.0005121381,0.0005414449],"category_scores_gemma":[0.000290014,0.0001804189,0.0002064282,0.0002389446,0.0004905831,0.0004580347,0.0001800112,0.000617233,0.0003188283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000687608,"about_ca_system_score_gemma":0.0004955941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002554588,"about_ca_topic_score_gemma":0.001856327,"domain_scores_codex":[0.9999174,0.00002376652,0.000004062817,0.00002474676,0.00001333967,0.00001673136],"domain_scores_gemma":[0.9998809,0.00003892969,0.0000180496,0.00001495384,0.00002434302,0.00002281949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003904505,0.00003175793,0.000475797,0.00006791314,0.000007027013,0.0001205182,0.00005398818,0.0004115677,0.9821619,0.001548054,0.0003330726,0.01439782],"study_design_scores_gemma":[0.00004793383,0.0007674381,0.001915637,0.00001989203,0.00004715663,0.0008884784,0.00007282903,0.006049058,0.9795734,0.0004408134,0.01015983,0.00001757548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8555405,0.02779385,0.1008905,0.00179099,0.0001220408,0.0001137394,0.0002087167,0.0004626861,0.01307698],"genre_scores_gemma":[0.9404213,0.005924921,0.04781248,0.0002277492,0.0000318764,0.00002913697,0.0002350438,0.00008606777,0.005231423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002554588,"threshold_uncertainty_score":0.005079448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09502133016425549,"score_gpt":0.4407800354303775,"score_spread":0.345758705266122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}