{"id":"W2115731959","doi":"10.1016/s8756-3282(03)00215-1","title":"Endothelin-1 promotes osteoprogenitor proliferation and differentiation in fetal rat calvarial cell cultures","year":2003,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto Western Hospital; University of Toronto","funders":"Canadian Orthopaedic Foundation; University Health Network","keywords":"Calvaria; Osteocalcin; Osteoblast; Alkaline phosphatase; Endocrinology; Downregulation and upregulation; Cell growth; Internal medicine; Endothelin 1; Cellular differentiation; Biology; Chemistry; Molecular biology; Medicine; In vitro; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006327941,0.00009230458,0.00008630199,0.00002205988,0.00004075184,0.00003006011,0.00002490388,0.00007913299,0.0000125176],"category_scores_gemma":[0.00008976109,0.00007829685,0.00002918292,0.00002904235,0.00002183354,0.000004961256,0.00001687697,0.00003414919,0.000003951892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000304455,"about_ca_system_score_gemma":0.00003435664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008779216,"about_ca_topic_score_gemma":0.00003666519,"domain_scores_codex":[0.9994355,0.0000703674,0.0001221225,0.0001903041,0.00006738588,0.0001142519],"domain_scores_gemma":[0.9997802,0.000003538338,0.00004622516,0.0000966798,0.00002560994,0.00004774185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007430426,0.0001205025,0.01121926,0.00001801992,0.000004756376,0.000001722711,0.00005174273,0.000001971466,0.9876159,0.000198317,0.0001135007,0.0005800226],"study_design_scores_gemma":[0.001417352,0.00007701845,0.00971237,0.000003772636,0.00002275555,0.000007917747,0.00003775087,0.00002463267,0.9852047,0.0001893416,0.003166299,0.0001360806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966102,0.002381177,0.00027055,0.00003015409,0.0001387771,0.0002460185,0.00001722901,0.000006047001,0.000299909],"genre_scores_gemma":[0.9985531,0.00007381839,0.0003927136,0.00004824019,0.0002006257,0.00003490683,0.00008131021,0.000008959637,0.0006063104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003052798,"threshold_uncertainty_score":0.3192853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005208825429136127,"score_gpt":0.2176515791746501,"score_spread":0.2124427537455139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}