{"id":"W2115751707","doi":"10.1124/mol.105.017558","title":"Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1 Signaling Pathway in Rat Cardiac Fibroblasts","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Transactivation; Small interfering RNA; Chemistry; Protein tyrosine phosphatase; Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Epidermal growth factor receptor; Signal transduction; Reactive oxygen species; Molecular biology; Phosphatase; Cell biology; Cancer research; Biology; Biochemistry; Receptor; Transcription factor; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828601,0.0003041797,0.0001726856,0.0001927939,0.0002296212,0.0002130549,0.0002013631,0.0002459576,0.0009232985],"category_scores_gemma":[0.00008177602,0.0001933022,0.0003615308,0.0001263024,0.0002128366,0.0002767844,0.0001225145,0.0006009561,0.000181487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622883,"about_ca_system_score_gemma":0.0002097141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008733415,"about_ca_topic_score_gemma":0.001037199,"domain_scores_codex":[0.9998833,0.00001953397,0.000009096363,0.00001989526,0.00002563928,0.00004258753],"domain_scores_gemma":[0.999947,0.00001006532,0.00001245453,0.000008912427,0.00000740567,0.00001423262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001907684,0.00003941707,0.0001118952,0.0000164406,0.000003091921,0.00008283011,0.00001617192,0.00002152454,0.998963,0.0001677957,0.0000230401,0.0003640291],"study_design_scores_gemma":[0.00004212272,0.0002457143,0.007052346,0.0000034644,0.00002089396,0.0002750673,0.0000408887,0.0007019339,0.9907187,0.0001150978,0.0007791126,0.000004593937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956,0.001136687,0.001937005,0.00009932479,0.00002734864,0.00001247676,0.000116163,0.00002777342,0.001043405],"genre_scores_gemma":[0.9967245,0.0006062288,0.0005153473,0.00002780587,0.000008203035,0.00002116013,0.0002069277,0.000003815311,0.001885991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009232985,"threshold_uncertainty_score":0.003088772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740470089798422,"score_gpt":0.2364063493146573,"score_spread":0.2190016484166731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}