{"id":"W2115779804","doi":"10.1038/ng.2802","title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","year":2013,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4659,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Medical Research Council; Hjartavernd; National Institutes of Health; Karl-Franzens-Universität Graz; Perelman School of Medicine, University of Pennsylvania; Háskóli Íslands; Erasmus Medisch Centrum; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Versus Arthritis; Cardiff University; National Institute on Aging; National Institute for Health and Care Research; University of Miami; Wellcome Trust; Dr. John T. MacDonald Foundation; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Medizinische Universität Graz; Alzheimer's Association; Llywodraeth Cymru; University of Washington; School of Medicine, Boston University; Vanderbilt University; Universität Zürich; University of Pennsylvania","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Apolipoprotein E; Disease; Biology; Alzheimer's disease; Genetic association; Genetics; Meta-analysis; Locus (genetics); Genotype; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004180658,0.002244522,0.005435397,0.002414158,0.0002769991,0.0008703587,0.001069884,0.001054419,0.00228483],"category_scores_gemma":[0.007770199,0.0007338578,0.01042882,0.003115678,0.0002938722,0.0006702247,0.0008101808,0.0008405285,0.0002302783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006681714,"about_ca_system_score_gemma":0.001292217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002942796,"about_ca_topic_score_gemma":0.01067693,"domain_scores_codex":[0.9981424,0.0007831531,0.0004051453,0.0003380071,0.0002454152,0.00008590109],"domain_scores_gemma":[0.9955665,0.003444637,0.0004767202,0.0002047524,0.0002420614,0.00006514132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006603396,0.0001062443,0.04179633,0.1057194,0.608639,0.0009585416,0.0001458793,0.0011827,0.00236737,0.0005579661,0.006361787,0.2255614],"study_design_scores_gemma":[0.001388969,0.0005610414,0.03988641,0.006901314,0.9330888,0.0009286272,0.0000784471,0.0002446998,0.0005483491,0.001629994,0.01468321,0.00006015929],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009270372,0.9881841,0.001029052,0.0003889365,0.0001804133,0.00003492793,0.0005135177,0.0000273211,0.0003712559],"genre_scores_gemma":[0.2109072,0.7813709,0.003721008,0.001301427,0.00042132,0.0001182948,0.001572469,0.00002718038,0.0005600587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005435397,"threshold_uncertainty_score":0.02210969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1775860596025934,"score_gpt":0.4292613596696662,"score_spread":0.2516753000670727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}