{"id":"W2115810559","doi":"10.1242/jeb.01491","title":"Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium","year":2005,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Francis Xavier University","funders":"","keywords":"Protein kinase C; Chelerythrine; Okadaic acid; Bisindolylmaleimide; DIDS; Biology; Dephosphorylation; Cell biology; MAPK/ERK pathway; Protein kinase A; p38 mitogen-activated protein kinases; Phosphorylation; Cotransporter; Chloride channel; Kinase; Molecular biology; Biophysics; Biochemistry; Chemistry; Phosphatase; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003298567,0.0001280499,0.0002250979,0.0000985581,0.00003681462,0.000009710066,0.00007778387,0.0001902063,0.00003610197],"category_scores_gemma":[0.00004908261,0.0001142846,0.00007874008,0.0000613856,0.00008192659,0.00001559549,0.00005187202,0.0001142395,0.000001889209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005180682,"about_ca_system_score_gemma":0.00003205324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001087869,"about_ca_topic_score_gemma":0.000005215324,"domain_scores_codex":[0.9989824,0.00009580694,0.0004803599,0.0001784033,0.00009464133,0.0001684295],"domain_scores_gemma":[0.9994314,0.00002143127,0.0003081124,0.00009022249,0.00008075991,0.00006812387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000194973,0.00007015596,0.001055642,0.000004805366,0.00002446004,0.000001600821,0.0002181011,0.0002968553,0.9968408,0.00001004033,0.0003561331,0.000926415],"study_design_scores_gemma":[0.0009446402,0.0004486416,0.0004270593,0.00001833349,0.000006946408,0.00006442445,0.0007248103,0.0006975559,0.9899036,0.00001300374,0.006637058,0.0001139598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962025,0.002488934,0.0003455534,0.0002489353,0.0004927143,0.00009569395,0.000007947672,0.000002451701,0.0001152958],"genre_scores_gemma":[0.9977731,0.0004756159,0.0008749079,0.0002538178,0.0005018022,0.00000174062,0.00005030302,0.00001283146,0.00005593162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00693725,"threshold_uncertainty_score":0.4660392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008041643592426095,"score_gpt":0.2491170699552951,"score_spread":0.241075426362869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}