{"id":"W2115810559","doi":"10.1242/jeb.01491","title":"Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium","year":2005,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Francis Xavier University","funders":"","keywords":"Protein kinase C; Chelerythrine; Okadaic acid; Bisindolylmaleimide; DIDS; Biology; Dephosphorylation; Cell biology; MAPK/ERK pathway; Protein kinase A; p38 mitogen-activated protein kinases; Phosphorylation; Cotransporter; Chloride channel; Kinase; Molecular biology; Biophysics; Biochemistry; Chemistry; Phosphatase; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053441,0.000350768,0.0004211686,0.0001681429,0.0001904729,0.0002102354,0.0001625529,0.0002599147,0.001362945],"category_scores_gemma":[0.00008246774,0.0001504598,0.0004106835,0.0001290757,0.0002281299,0.0003228037,0.0002568766,0.0005503349,0.0002518506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818207,"about_ca_system_score_gemma":0.0001951679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006227653,"about_ca_topic_score_gemma":0.000738266,"domain_scores_codex":[0.9999,0.00001125073,0.00000972311,0.00001470316,0.00002547497,0.00003873401],"domain_scores_gemma":[0.9999478,0.000005302086,0.00001163509,0.000006735323,0.000008263875,0.00002023546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002670866,0.00001186656,0.0002855418,0.00004014818,0.000003951724,0.0001220733,0.00003364904,0.00002003948,0.9987336,0.00003334944,0.0000178539,0.0004309102],"study_design_scores_gemma":[0.00004133489,0.0005882458,0.04389127,0.000007532956,0.00003946581,0.0004353357,0.0002006587,0.0009721614,0.9521557,0.00006855987,0.001588787,0.00001084357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99723,0.001208536,0.0004842166,0.00009530264,0.00002232882,0.00001592111,0.0002135039,0.00002592489,0.0007042479],"genre_scores_gemma":[0.9966002,0.0008296804,0.0005517986,0.00005995505,0.00001230076,0.00004059038,0.0003277332,0.000007612172,0.001570067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362945,"threshold_uncertainty_score":0.004559517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008041643592426095,"score_gpt":0.2491170699552951,"score_spread":0.241075426362869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}