{"id":"W2115841348","doi":"10.1038/labinvest.2010.144","title":"Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action","year":2010,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Downregulation and upregulation; Insulin receptor; Protein kinase B; Endocrinology; Receptor; Insulin; Signal transduction; Biology; Internal medicine; Cell adhesion molecule; Cancer research; Cell biology; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004265312,0.0002264724,0.0003092189,0.0005194984,0.0002685781,0.0005957917,0.0003561818,0.0004887569,0.00345692],"category_scores_gemma":[0.0006125062,0.0001956008,0.0003245581,0.0002087995,0.0003795933,0.0002316813,0.0001916479,0.0006167755,0.0005124633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005700652,"about_ca_system_score_gemma":0.000567959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00200069,"about_ca_topic_score_gemma":0.003288539,"domain_scores_codex":[0.9996612,0.00009741719,0.00002568437,0.00005380191,0.00009061232,0.00007127214],"domain_scores_gemma":[0.9996122,0.000164707,0.00005959434,0.00005209563,0.00005030887,0.00006120583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001110256,0.0001276053,0.001148283,0.0001198952,0.00004405152,0.00009015686,0.00003264159,0.00005740034,0.9859468,0.0005741249,0.0003298276,0.01041893],"study_design_scores_gemma":[0.0001049811,0.0006507744,0.006353823,0.00001068437,0.00003347807,0.0004144461,0.00004876767,0.0003272186,0.9825934,0.0001390093,0.009318113,0.000005308045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644076,0.01758068,0.003307868,0.001246434,0.0002021464,0.000090266,0.0005108872,0.0002192787,0.01243503],"genre_scores_gemma":[0.9907094,0.001751461,0.001901095,0.000278952,0.00003482652,0.00003567148,0.0002561425,0.00002556189,0.005006759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00345692,"threshold_uncertainty_score":0.01156455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244299876256985,"score_gpt":0.3190390496206736,"score_spread":0.2865960508581037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}